Cell Biology Antibodies 2

Anti-SEC23A Antibody (CAB12101)

(No reviews yet) Write a Review
SKU:
CAB12101
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-SEC23A Antibody
Antibody SKU:CAB12101
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SEC23A (NP_006355.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:B cells, LO2, HeLa, SGC-7901, HT-29, Mouse brain, Mouse liver, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human SEC23A (NP_006355.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTTY LEFI QQNE ERDG VRFS WNVW PSSR LEAT RMVV PVAA LFTP LKER PDLP PIQY EPVL CSRT TCRA VLNP LCQV DYRA KLWA CNFC YQRN QFPP SYAG ISEL NQPA ELLP QFSS IEYV VLRG PQMP LIFL YVVD TCME DEDL QALK ES
Gene ID:10484
Uniprot:Q15436
Cellular Location:Golgi apparatus membrane, Peripheral membrane protein, Smooth endoplasmic reticulum membrane
Calculated MW:63kDa/86kDa
Observed MW:86kDa
Synonyms:SEC23A, CLSD
Background:The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.
UniProt Protein Function:SEC23A: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex. COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with SEC23IP. Interacts with HTR4. Interacts with SLC6A4. Interacts with SEC16A. Belongs to the SEC23/SEC24 family. SEC23 subfamily.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q21.1

Cellular Component: COPII vesicle coat; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; perinuclear region of cytoplasm; smooth endoplasmic reticulum membrane

Molecular Function:protein binding; zinc ion binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; intracellular protein transport; vesicle-mediated transport

Disease: Craniolenticulosutural Dysplasia

NCBI Summary:The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]
UniProt Code:Q15436
NCBI GenInfo Identifier:143811354
NCBI Gene ID:10484
NCBI Accession:Q15436.2
UniProt Secondary Accession:Q15436,Q8NE16, B2R5P4, B3KXI2,
UniProt Related Accession:Q15436
Molecular Weight:63,101 Da
NCBI Full Name:Protein transport protein Sec23A
NCBI Synonym Full Names:Sec23 homolog A, coat complex II component
NCBI Official Symbol:SEC23A  
NCBI Official Synonym Symbols:CLSD  
NCBI Protein Information:protein transport protein Sec23A
UniProt Protein Name:Protein transport protein Sec23A
UniProt Synonym Protein Names:SEC23-related protein A
Protein Family:SEC23-interacting protein
UniProt Gene Name:SEC23A  
UniProt Entry Name:SC23A_HUMAN
Anti-SEC23A Antibody (CAB12101)Western blot analysis of extracts of various cell lines, using SEC23A antibody (CAB12101) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
View AllClose

0 Reviews

View AllClose

Related Products