Developmental Biology
Anti-SDC2 Antibody (CAB12500)
- SKU:
- CAB12500
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-SDC2 Antibody |
| Antibody SKU: | CAB12500 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-144 of human SDC2 (NP_002989.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, U-251MG, HepG2, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-144 of human SDC2 (NP_002989.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ESRA ELTS DKDM YLDN SSIE EASG VYPI DDDD YASA SGSG ADED VESP ELTT SRPL PKIL LTSA APKV ETTT LNIQ NKIP AQTK SPEE TDKE KVHL SDSE RKMD PAEE DTNV YTEK HSDS LFKR TE |
| Gene ID: | 6383 |
| Uniprot: | P34741 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 22kDa |
| Observed MW: | 37kDa |
| Synonyms: | SDC2, CD362, HSPG, HSPG1, SYND2 |
| Background: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. |
| UniProt Protein Function: | syndecan-2: a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Preferentially expressed in cells of mesenchymal origin. Is tyrosine phosphorylated and forms a complex with EphB2 in mouse brain. Plays a role in mediating adhesion and proliferation of colon carcinoma cells. |
| UniProt Protein Details: | Protein type:Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 8q22-q23 Cellular Component: lysosomal lumen; cell soma; Golgi lumen; integral to membrane; plasma membrane; synapse Molecular Function:protein binding; PDZ domain binding Biological Process: axon guidance; phototransduction, visible light; extracellular matrix organization and biogenesis; wound healing; glycosaminoglycan metabolic process; dendrite morphogenesis; regulation of dendrite morphogenesis; pathogenesis; response to caffeine; chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; carbohydrate metabolic process; ephrin receptor signaling pathway; response to hypoxia; retinoid metabolic process |
| NCBI Summary: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P34741 |
| NCBI GenInfo Identifier: | 158962336 |
| NCBI Gene ID: | 6383 |
| NCBI Accession: | P34741.2 |
| UniProt Related Accession: | P34741 |
| Molecular Weight: | |
| NCBI Full Name: | Syndecan-2 |
| NCBI Synonym Full Names: | syndecan 2 |
| NCBI Official Symbol: | SDC2 |
| NCBI Official Synonym Symbols: | HSPG; CD362; HSPG1; SYND2 |
| NCBI Protein Information: | syndecan-2 |
| UniProt Protein Name: | Syndecan-2 |
| UniProt Synonym Protein Names: | Fibroglycan; Heparan sulfate proteoglycan core protein; HSPG; CD_antigen: CD362 |
| Protein Family: | Syndecan |
| UniProt Gene Name: | SDC2 |
| UniProt Entry Name: | SDC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SDC2 Antibody (CAB12500) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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