Signal Transduction Antibodies 3
Anti-SCG5 Antibody (CAB6308)
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- SKU:
- CAB6308
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-SCG5 Antibody |
| Antibody SKU: | CAB6308 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-176 of human SCG5 (NP_001138229.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse pancreas, Mouse brain, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-176 of human SCG5 (NP_001138229.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YSPR TPDR VSEA DIQR LLHG VMEQ LGIA RPRV EYPA HQAM NLVG PQSI EGGA HEGL QHLG PFGN IPNI VAEL TGDN IPKD FSED QGYP DPPN PCPV GKTA DDGC LENT PDTA EFSR EFQL HQHL FDPE HDYP GLGK WNKK LLYE KMKG GE |
| Gene ID: | 6447 |
| Uniprot: | P05408 |
| Cellular Location: | Secreted |
| Calculated MW: | 23kDa |
| Observed MW: | 24kDa |
| Synonyms: | SCG5, 7B2, P7B2, SGNE1, SgV |
| Background: |
| UniProt Protein Function: | 7B2: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. Belongs to the 7B2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Chaperone; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 15q13-q14 Cellular Component: extracellular region; secretory granule Molecular Function:enzyme inhibitor activity; protein binding; GTP binding; unfolded protein binding Biological Process: intracellular protein transport; neuropeptide signaling pathway; negative regulation of catalytic activity; peptide hormone processing; regulation of hormone secretion |
| UniProt Code: | P05408 |
| NCBI GenInfo Identifier: | 23830842 |
| NCBI Gene ID: | 6447 |
| NCBI Accession: | P05408.2 |
| UniProt Secondary Accession: | P05408,P01164, Q6FHD0, Q9BS38, |
| UniProt Related Accession: | P05408 |
| Molecular Weight: | 212 |
| NCBI Full Name: | Neuroendocrine protein 7B2 |
| NCBI Synonym Full Names: | secretogranin V (7B2 protein) |
| NCBI Official Symbol: | SCG5 |
| NCBI Official Synonym Symbols: | 7B2; SgV; P7B2; SGNE1 |
| NCBI Protein Information: | neuroendocrine protein 7B2; secretogranin-5; pituitary polypeptide; prohormone convertase chaperone; secretory granule endocrine protein I; secretory granule, neuroendocrine protein 1 (7B2 protein) |
| UniProt Protein Name: | Neuroendocrine protein 7B2 |
| UniProt Synonym Protein Names: | Pituitary polypeptide; Secretogranin V; Secretogranin-5; Secretory granule endocrine protein ICleaved into the following 2 chains:N-terminal peptide; C-terminal peptide |
| Protein Family: | Neuroendocrine protein |
| UniProt Gene Name: | SCG5 |
| UniProt Entry Name: | 7B2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SCG5 antibody (CAB6308) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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