Cell Biology Antibodies 17

Anti-SARS-CoV-2 Spike Antibody, S1 Monoclonal (CAB20022)

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SKU:
CAB20022
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Description

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Antibody Name:SARS-CoV-2 spike antibody, S1 Monoclonal
Antibody SKU:CAB20022
Antibody Size:50uL, 100uL
Application:ELISA, FC, IHC, IF, IP
Reactivity:SARS-CoV-2
Host Species:Rabbit
Immunogen:Recombinant fusion protein of 2019-nCoV Spike S1.
Application:ELISA, FC, IHC, IF, IP
Recommended Dilution:ELISA 1:1000 - 1:5000
FC 1:50 - 1:200
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200
Reactivity:SARS-CoV-2
Positive Samples:
Immunogen:Recombinant fusion protein of 2019-nCoV Spike S1.
Purification Method:Affinity purification
Storage Buffer:Store at 4°C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence.
Gene ID:43740568
Uniprot:P0DTC2
Cellular Location:Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion (By similarity).
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Background:The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
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NCBI Summary:
UniProt Code:P0DTC2
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UniProt Secondary Accession:P0DTC2
UniProt Related Accession:P0DTC2
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Protein Family:SMY2
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Additional Information

Product Type:
Antibody
Reactivity:
SARS-CoV-2
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
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