KO Validated Antibodies 1

Anti-SAMHD1 Antibody (CAB7794)[KO Validated]

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SKU:
CAB7794
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-SAMHD1 Antibody [KO Validated]
Antibody SKU:CAB7794
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 387-626 of human SAMHD1 (NP_056289.2).
Application:WB IHC IF IP
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 IP 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, HeLa, MCF-7, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 387-626 of human SAMHD1 (NP_056289.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TDAF LKAD DYIE ITGA GGKK YRIS TAID DMEA YTKL TDNI FLEI LYST DPKL KDAR EILK QIEY RNLF KYVG ETQP TGQI KIKR EDYE SLPK EVAS AKPK VLLD VKLK AEDF IVDV INMD YGMQ EKNP IDHV SFYC KTAP NRAI RITK NQVS QLLP EKFA EQLI RVYC KKVD RKSL YAAR QYFV QWCA DRNF TKPQ DGDV IAPL ITPQ KKEW NDST SVQN PTRL REAS KSRV QLFK DDPM
Gene ID:25939
Uniprot:Q9Y3Z3
Cellular Location:Nucleus
Calculated MW:63kDa/68kDa/72kDa
Observed MW:72kDa
Synonyms:SAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88
Background:This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
NCBI Summary:This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]
UniProt Code:Q9Y3Z3
NCBI GenInfo Identifier:38016914
NCBI Gene ID:25939
NCBI Accession:NP_056289.2
UniProt Secondary Accession:Q9Y3Z3,Q5JXG8, Q8N491, Q9H004, Q9H005, Q9H3U9, B4E2A5 E1P5V2,
UniProt Related Accession:Q9Y3Z3
Molecular Weight:68,122 Da
NCBI Full Name:deoxynucleoside triphosphate triphosphohydrolase SAMHD1
NCBI Synonym Full Names:SAM domain and HD domain 1
NCBI Official Symbol:SAMHD1  
NCBI Official Synonym Symbols:DCIP; CHBL2; HDDC1; MOP-5; SBBI88  
NCBI Protein Information:deoxynucleoside triphosphate triphosphohydrolase SAMHD1
UniProt Protein Name:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
UniProt Synonym Protein Names:Dendritic cell-derived IFNG-induced protein; DCIP; Monocyte protein 5; MOP-5; SAM domain and HD domain-containing protein 1
Protein Family:Deoxynucleoside triphosphate triphosphohydrolase
UniProt Gene Name:SAMHD1  
UniProt Entry Name:SAMH1_HUMAN
Anti-SAMHD1 Antibody [KO Validated] (CAB7794)Western blot analysis of extracts of various cell lines, using SAMHD1 antibody (CAB7794) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-SAMHD1 Antibody [KO Validated] (CAB7794)Western blot analysis of extracts from normal (control) and SAMHD1 knockout (KO) HeLa cells, using SAMHD1 antibody (CAB7794) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
Anti-SAMHD1 Antibody [KO Validated] (CAB7794)Immunohistochemistry of paraffin-embedded human liver cancer using [KO Validated] SAMHD1 Rabbit pAb (CAB7794) at dilution of 1:100 (40x lens).
Anti-SAMHD1 Antibody [KO Validated] (CAB7794)Immunofluorescence analysis of A549 cells using SAMHD1 antibody (CAB7794). Blue: DAPI for nuclear staining.
Anti-SAMHD1 Antibody [KO Validated] (CAB7794)Immunoprecipitation analysis of 200ug extracts of HeLa cells using 3ug SAMHD1 antibody (CAB7794). Western blot was performed from the immunoprecipitate using SAMHD1 antibody (CAB7794) at a dilition of 1:1000.
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