ChIP Antibodies
Anti-SALL4 Antibody (CAB7124)
- SKU:
- CAB7124
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-SALL4 Antibody |
| Antibody SKU: | CAB7124 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SALL4 (NP_065169.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, HeLa, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SALL4 (NP_065169.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSRR KQAK PQHI NSEE DQGE QQPQ QQTP EFAD AAPA APAA GELG APVN HPGN DEVA SEDE ATVK RLRR EETH VCEK CCAE FFSI SEFL EHKK NCTK NPPV LIMN DSEG PVPS EDFS GAVL SHQP TSPG SKDC HREN GGSS EDMK EKPD AESV VYLK TETA LPPT PQDI SYLA KGKV ANTN VTLQ ALRG TKVA VNQR SADA LPAP VPGA NSIP WVLE QILC |
| Gene ID: | 57167 |
| Uniprot: | Q9UJQ4 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 65kDa/112kDa |
| Observed MW: | 80kDa |
| Synonyms: | SALL4, DRRS, HSAL4, ZNF797 |
| Background: | This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | SALL4: a transcription factor and oncofetal protein expressed embryonically and in the testis. Plays a key role in maintenance and self-renewal of embryonic stem cells. Interacts with NANOG and OCT4. Ectopically expressed in acute B-cell lymphoblastic leukemia (B-ALL) and myeloid leukemia (AML), playing a role in the survival of B-ALL cells and in myeloid leukemogenesis. Aberrantly expressed in multiple carcinomas including human gastric carcinoma and hepatocellular carcinoma. Maintains the stem cell qualities of EpCAM-positive hepatocellular carcinoma cells. Expressed in primary human endometrial cancer samples but not normal or hyperplastic endometrial cells. Its expression in carcinomas positively correlates with metastatic potential and poor patient survival. Specifically binds the c-Myc promoter region in endometrial cancer cells, apparently increasing c-Myc expression. Belongs to the sal C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding Chromosomal Location of Human Ortholog: 20q13.2 Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: multicellular organismal development; regulation of transcription, DNA-dependent; signal transduction; somatic stem cell maintenance; transcription from RNA polymerase II promoter Disease: Duane-radial Ray Syndrome; Ivic Syndrome |
| NCBI Summary: | This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q9UJQ4 |
| NCBI GenInfo Identifier: | 24212387 |
| NCBI Gene ID: | 57167 |
| NCBI Accession: | Q9UJQ4.1 |
| UniProt Secondary Accession: | Q9UJQ4,Q540H3, Q6Y8G6, A2A2D8, |
| UniProt Related Accession: | Q9UJQ4 |
| Molecular Weight: | 65,708 Da |
| NCBI Full Name: | Sal-like protein 4 |
| NCBI Synonym Full Names: | spalt like transcription factor 4 |
| NCBI Official Symbol: | SALL4 |
| NCBI Official Synonym Symbols: | DRRS; HSAL4; ZNF797 |
| NCBI Protein Information: | sal-like protein 4 |
| UniProt Protein Name: | Sal-like protein 4 |
| UniProt Synonym Protein Names: | Zinc finger protein 797; Zinc finger protein SALL4 |
| Protein Family: | Sal-like protein |
| UniProt Gene Name: | SALL4 |
| UniProt Entry Name: | SALL4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SALL4 Antibody (CAB7124) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunofluorescence analysis of A549 cells using SALL4 antibody (CAB7124). Blue: DAPI for nuclear staining. |
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