Signal Transduction Antibodies 2
Anti-S1PR3 Antibody (CAB15664)
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- SKU:
- CAB15664
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-S1PR3 Antibody |
| Antibody SKU: | CAB15664 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human S1PR3 (NP_005217.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse heart, Mouse kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human S1PR3 (NP_005217.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GKKT FSLS PTVW FLRE GSMF VALG ASTC SLLA IAIE RHLT MIKM RPYD ANKR HRVF LLIG MCWL IAFT LGAL PILG WNCL HNLP DCST ILPL YSKK YIAF C |
| Gene ID: | 1903 |
| Uniprot: | Q99500 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 42kDa |
| Observed MW: | 42kDa |
| Synonyms: | S1PR3, EDG-3, EDG3, LPB3, S1P3 |
| Background: | This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. |
| UniProt Protein Function: | S1PR3: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 9q22.1-q22.2 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:G-protein coupled receptor activity; integrin binding; lipid binding; protein binding Biological Process: anatomical structure morphogenesis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation |
| NCBI Summary: | This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99500 |
| NCBI GenInfo Identifier: | 42560554 |
| NCBI Gene ID: | 1903 |
| NCBI Accession: | Q99500.2 |
| UniProt Secondary Accession: | Q99500,Q5SQD8, Q7Z5I2, |
| UniProt Related Accession: | Q99500 |
| Molecular Weight: | 42,250 Da |
| NCBI Full Name: | Sphingosine 1-phosphate receptor 3 |
| NCBI Synonym Full Names: | sphingosine-1-phosphate receptor 3 |
| NCBI Official Symbol: | S1PR3 |
| NCBI Official Synonym Symbols: | EDG3; LPB3; S1P3; EDG-3 |
| NCBI Protein Information: | sphingosine 1-phosphate receptor 3 |
| UniProt Protein Name: | Sphingosine 1-phosphate receptor 3 |
| UniProt Synonym Protein Names: | Endothelial differentiation G-protein coupled receptor 3; Sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3 |
| Protein Family: | Sphingosine 1-phosphate receptor |
| UniProt Gene Name: | S1PR3 |
| UniProt Entry Name: | S1PR3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using S1PR3 antibody (CAB15664) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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