Signal Transduction Antibodies 1
Anti-S100P Antibody (CAB14780)
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- SKU:
- CAB14780
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-S100P Antibody |
| Antibody SKU: | CAB14780 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-95 of human S100P (NP_005971.1). |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, BxPC-3 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-95 of human S100P (NP_005971.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTEL ETAM GMII DVFS RYSG SEGS TQTL TKGE LKVL MEKE LPGF LQSG KDKD AVDK LLKD LDAN GDAQ VDFS EFIV FVAA ITSA CHKY FEKA GLK |
| Gene ID: | 6286 |
| Uniprot: | P25815 |
| Cellular Location: | Cell projection, Cytoplasm, Nucleus, microvillus membrane |
| Calculated MW: | 10kDa |
| Observed MW: | 10KDa |
| Synonyms: | S100P, MIG9 |
| Background: | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. |
| UniProt Protein Function: | May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). |
| NCBI Summary: | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P25815 |
| NCBI GenInfo Identifier: | 134142 |
| NCBI Gene ID: | 6286 |
| NCBI Accession: | P25815.2 |
| UniProt Secondary Accession: | P25815,Q5J7W2, |
| UniProt Related Accession: | P25815 |
| Molecular Weight: | 10,400 Da |
| NCBI Full Name: | Protein S100-P |
| NCBI Synonym Full Names: | S100 calcium binding protein P |
| NCBI Official Symbol: | S100P |
| NCBI Official Synonym Symbols: | MIG9 |
| NCBI Protein Information: | protein S100-P |
| UniProt Protein Name: | Protein S100-P |
| UniProt Synonym Protein Names: | Migration-inducing gene 9 protein; MIG9; Protein S100-E; S100 calcium-binding protein P |
| Protein Family: | Protein |
| UniProt Gene Name: | S100P |
| UniProt Entry Name: | S100P_HUMAN |
 | Western blot analysis of extracts of various cell lines, using S100P antibody (CAB14780) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using S100P antibody (CAB14780) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using S100P antibody (CAB14780) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using S100P antibody (CAB14780) at dilution of 1:100 (40x lens). |
 | Immunoprecipitation analysis of 300ug extracts of HT-29 cells using 3ug S100P antibody (CAB14780). Western blot was performed from the immunoprecipitate using S100P antibody (CAB14780) at a dilition of 1:1000. |
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