Cell Biology Antibodies 2

Anti-RPS24 Antibody (CAB12123)

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SKU:
CAB12123
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RPS24 Antibody
Antibody SKU:CAB12123
Antibody Size:20uL, 50uL, 100uL
Application:WB IP
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RPS24 (NP_148982.1).
Application:WB IP
Recommended Dilution:WB 1:500 - 1:2000 IP 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, 293T, HeLa, Jurkat, Mouse liver, Mouse pancreas, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RPS24 (NP_148982.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNDT VTIR TRKF MTNR LLQR KQMV IDVL HPGK ATVP KTEI REKL AKMY KTTP DVIF VFGF RTHF GGGK TTGF GMIY DSLD YAKK NEPK HRLA RHGL YEKK KTSR KQRK ERKN RMKK VRGT AKAN VGAG KK
Gene ID:6229
Uniprot:P62847
Cellular Location:
Calculated MW:15kDa/32kDa
Observed MW:19kDa
Synonyms:RPS24, DBA3, S24
Background:Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia.
UniProt Protein Function:RPS24: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Defects in RPS24 are the cause of Diamond-Blackfan anemia type 3 (DBA3). DBA3 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S24e family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding; Ribosomal; Translation

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: cytosol; membrane; nucleoplasm; nucleus; small ribosomal subunit

Molecular Function:RNA binding; translation initiation factor binding

Biological Process: erythrocyte homeostasis; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); mRNA catabolic process, nonsense-mediated decay; ribosomal small subunit biogenesis and assembly; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription

Disease: Diamond-blackfan Anemia 3

NCBI Summary:Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008]
UniProt Code:P62847
NCBI GenInfo Identifier:51338645
NCBI Gene ID:6229
NCBI Accession:P62847.1
UniProt Secondary Accession:P62847,P16632, Q5T0P7, Q5T0P8, Q7Z3D1, E7EPK6,
UniProt Related Accession:P62847
Molecular Weight:15kDa
NCBI Full Name:40S ribosomal protein S24
NCBI Synonym Full Names:ribosomal protein S24
NCBI Official Symbol:RPS24  
NCBI Official Synonym Symbols:S24; DBA3  
NCBI Protein Information:40S ribosomal protein S24
UniProt Protein Name:40S ribosomal protein S24
UniProt Synonym Protein Names:Small ribosomal subunit protein eS24
Protein Family:40S ribosomal protein
UniProt Gene Name:RPS24  
Anti-RPS24 Antibody (CAB12123)Western blot analysis of extracts of various cell lines, using RPS24 antibody (CAB12123) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-RPS24 Antibody (CAB12123)Immunoprecipitation analysis of 200ug extracts of HeLa cells using 3ug RPS24 antibody ( A12123). Western blot was performed from the immunoprecipitate using RPS24 antibody ( A12123) at a dilition of 1:1000.
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