Anti-RORbeta Antibody (CAB19753)

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SKU:
CAB19753
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NR1F2
Synonyms:
ROR-BETA
Synonyms:
RZR-BETA
Synonyms:
RZRB
Synonyms:
bA133M9.1

Description

Product Name:ROR? Rabbit mAb
Product Code:CAB19753
Size:20uL, 50uL, 100uL
Synonyms:NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ROR?
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:PC-12, C6, SH-SY5Y, Y79, Mouse eye
Immunogen:A synthesized peptide derived from human ROR?
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6096
Uniprot:Q92753
Calculated MW:53kDa
Observed MW:53KDa
UniProt Protein Function:RORB: Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; Nuclear receptorChromosomal Location of Human Ortholog: 9q22Cellular Component: nucleoplasm; nucleusMolecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; transcription factor bindingBiological Process: transcription initiation from RNA polymerase II promoter; retinal rod cell development; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; rhythmic process; regulation of circadian rhythm; eye photoreceptor cell development; regulation of transcription, DNA-dependent; visual perception; retinal cone cell development; retina development in camera-type eye; negative regulation of osteoblast differentiation; gene expression; steroid hormone mediated signaling; negative regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]
UniProt Code:Q92753
NCBI GenInfo Identifier:124028630
NCBI Gene ID:124028630
NCBI Accession:Q92753.3
UniProt Secondary Accession:Q92753,Q8WX73
UniProt Related Accession:Q92753
Molecular Weight:53220
NCBI Full Name:Nuclear receptor ROR-beta
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Nuclear receptor ROR-beta
UniProt Synonym Protein Names:Nuclear receptor RZR-beta; Nuclear receptor subfamily 1 group F member 2; Retinoid-related orphan receptor-beta
Protein Family:Nuclear receptor
UniProt Gene Name:RORB  
UniProt Entry Name:RORB_HUMAN
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