Developmental Biology

Anti-RNF17 Antibody (CAB13813)

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SKU:
CAB13813
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-RNF17 Antibody
Antibody SKU:CAB13813
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 900-1200 of human RNF17 (NP_112567.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 900-1200 of human RNF17 (NP_112567.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VSAK SLPN ENFQ SLYN KELP VHIC NVIS PEKI YVQW LLTE NLLN SLEE KMIA AYEN SKWE PVKW ENDM HCAV KIQD KNQW RRGQ IIRM VTDT LVEV LLYD VGVE LVVN VDCL RKLE ENLK TMGR LSLE CSLV DIRP AGGS DKWT ATAC DCLS LYLT GAVA TIIL QVDS EENN TTWP LPVK IFCR DEKG ERVD VSKY LIKK GLAL RERR INNL DNSH SLSE KSLE VPLE QEDS VVTN CIKT NFDP DKKT ADII SEQK VSEF QEKI LEPR TTRG YKPP AIPN MNVF EATV SCVG DDGT IFVV P
Gene ID:56163
Uniprot:Q9BXT8
Cellular Location:Cytoplasm, Nucleus
Calculated MW:50kDa/73kDa/179kDa/183kDa/184kDa
Observed MW:185kDa
Synonyms:RNF17, Mmip-2, SPATA23, TDRD4
Background:This gene is similar to a mouse gene that encodes a testis-specific protein containing a RING finger domain. Alternatively spliced transcript variants encoding different isoforms have been found.
UniProt Protein Function:RNF17: Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 13q12.12

Cellular Component: cytoplasm; nucleus

Molecular Function:protein homodimerization activity; zinc ion binding

Biological Process: multicellular organismal development; spermatid development

UniProt Code:Q9BXT8
NCBI GenInfo Identifier:94421471
NCBI Gene ID:
NCBI Accession:NP_112567
Molecular Weight:
NCBI Full Name:RING finger protein 17 isoform 1
UniProt Protein Name:RING finger protein 17
UniProt Synonym Protein Names:Tudor domain-containing protein 4
Protein Family:RING finger protein
UniProt Gene Name:RNF17  
UniProt Entry Name:RNF17_HUMAN
Anti-RNF17 Antibody (CAB13813)Western blot analysis of extracts of A-549 cells, using RNF17 antibody (CAB13813) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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