Anti-Rhodopsin Antibody (CAB7245)
- SKU:
- CAB7245
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CSNBAD1
- Synonyms:
- OPN2
- Synonyms:
- RP4
Description
| Product Name: | Rhodopsin Rabbit mAb |
| Product Code: | CAB7245 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CSNBAD1, OPN2, RP4 |
| Applications: | WB, IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Rhodopsin |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse eye, Rat eye |
| Immunogen: | A synthesized peptide derived from human Rhodopsin |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 6010 |
| Uniprot: | P08100 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 39kDa |
| Observed MW: | 28-150kDa |
| UniProt Protein Function: | Rhodopsin: a G-protein coupled receptor. The light-absorbing visual pigment in Rod photoreceptor cells. Mediates vision in dim light. Consists of the apoprotein, opsin, covalently linked to cis-retinal. Defects in RHO are a cause of autosomal retinitis pigmentosa and congenital stationary night blindness. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 3q21-q24 Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; photoreceptor inner segment; photoreceptor outer segment; plasma membrane Molecular Function:G-protein coupled photoreceptor activity; G-protein coupled receptor activity; protein binding Biological Process: absorption of visible light; G-protein coupled receptor protein signaling pathway; phototransduction, visible light; regulation of rhodopsin mediated signaling; retinoid metabolic process; rhodopsin mediated signaling Disease: Fundus Albipunctatus; Night Blindness, Congenital Stationary, Autosomal Dominant 1; Retinitis Pigmentosa 4 |
| NCBI Summary: | Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08100 |
| NCBI GenInfo Identifier: | 129207 |
| NCBI Gene ID: | 6010 |
| NCBI Accession: | P08100.1 |
| UniProt Secondary Accession: | P08100,Q16414, Q2M249, |
| UniProt Related Accession: | P08100 |
| Molecular Weight: | 38,893 Da |
| NCBI Full Name: | Rhodopsin |
| NCBI Synonym Full Names: | rhodopsin |
| NCBI Official Symbol: | RHO |
| NCBI Official Synonym Symbols: | RP4; OPN2; CSNBAD1 |
| NCBI Protein Information: | rhodopsin |
| UniProt Protein Name: | Rhodopsin |
| UniProt Synonym Protein Names: | Opsin-2 |
| Protein Family: | Rhotekin |
| UniProt Gene Name: | RHO |
| UniProt Entry Name: | OPSD_HUMAN |
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