Cell Biology Antibodies 15
Anti-RHOA/RHOB/RHOC Antibody (CAB4855)
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- SKU:
- CAB4855
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ARH9
- Synonyms:
- ARHC
- Synonyms:
- H9
- Synonyms:
- RHOH9
- Research Area:
- Cell Biology
Description
| Product Name: | RHOA/RHOB/RHOC Rabbit mAb |
| Product Code: | CAB4855 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ARH9, ARHC, H9, RHOH9 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human RHOA/RHOB/RHOC |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, MCF7, NIH/3T3, SH-SY5Y, HUVEC, Mouse brain, Mouse kidney, Rat brain |
| Immunogen: | A synthesized peptide derived from human RHOA/RHOB/RHOC |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 389/387/388 |
| Uniprot: | P08134/P61586/P62745 |
| Calculated MW: | 22kDa |
| Observed MW: | 22KDa |
| UniProt Protein Function: | RHOC: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. |
| UniProt Protein Details: | Protein type:G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rho; G protein Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: cleavage furrow; cytosol; plasma membrane Molecular Function:protein binding; signal transducer activity Biological Process: apical junction assembly; cytokinesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of lipase activity; regulation of small GTPase mediated signal transduction |
| NCBI Summary: | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08134 |
| NCBI GenInfo Identifier: | 132543 |
| NCBI Gene ID: | 389 |
| NCBI Accession: | P08134.1 |
| UniProt Secondary Accession: | P08134,Q6ICN3, B3KSW1, |
| UniProt Related Accession: | P08134 |
| Molecular Weight: | 22,006 Da |
| NCBI Full Name: | Rho-related GTP-binding protein RhoC |
| NCBI Synonym Full Names: | ras homolog family member C |
| NCBI Official Symbol: | RHOC |
| NCBI Official Synonym Symbols: | H9; ARH9; ARHC; RHOH9 |
| NCBI Protein Information: | rho-related GTP-binding protein RhoC |
| UniProt Protein Name: | Rho-related GTP-binding protein RhoC |
| UniProt Synonym Protein Names: | Rho cDNA clone 9; h9 |
| Protein Family: | Rho-related GTP-binding protein |
| UniProt Gene Name: | RHOC |
| UniProt Entry Name: | RHOC_HUMAN |
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