Cell Biology Antibodies 16

Anti-RGS8 Antibody (CAB9987)

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SKU:
CAB9987
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RGS8 Antibody
Antibody SKU:CAB9987
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human RGS8 (NP_001095920.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Jurkat, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human RGS8 (NP_001095920.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAL LMPR RNKG MRTR LGCL SHKS DSCS DFTA ILPD KPNR ALKR LSTE EATR WADS FDVL LSHK YGVA AFRA FLKT EFSE ENLE FWLA CEEF KKTR STAK LVSK AHRI FEEF VDVQ APRE VNID FQTR EATR KNLQ EPSL TCFD QAQG KVHS LMEK DSYP RFLR SKMY LDLL SQSQ RRLS
Gene ID:85397
Uniprot:P57771
Cellular Location:
Calculated MW:20kDa/22kDa
Observed MW:17kDa/20kDa
Synonyms:RGS8
Background:This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.
UniProt Protein Function:Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.
NCBI Summary:This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
UniProt Code:P57771
NCBI GenInfo Identifier:13124465
NCBI Gene ID:85397
NCBI Accession:P57771.1
UniProt Secondary Accession:P57771,Q3SYD2, B4DGL9,
UniProt Related Accession:P57771
Molecular Weight:22,970 Da
NCBI Full Name:Regulator of G-protein signaling 8
NCBI Synonym Full Names:regulator of G-protein signaling 8
NCBI Official Symbol:RGS8  
NCBI Protein Information:regulator of G-protein signaling 8
UniProt Protein Name:Regulator of G-protein signaling 8
Protein Family:Regulator of G-protein signaling
UniProt Gene Name:RGS8  
UniProt Entry Name:RGS8_HUMAN
Anti-RGS8 Polyclonal Antibody (CAB9987)Western blot analysis of extracts of various cell lines, using RGS8 antibody (CAB9987) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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