Cell Biology Antibodies 13

Anti-RGCC Antibody (CAB17689)

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SKU:
CAB17689
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-RGCC Antibody
Antibody SKU:CAB17689
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of Human RGCC.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Mouse kidney, Mouse heart
Immunogen:A synthetic peptide of Human RGCC.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:28984
Uniprot:Q9H4X1
Cellular Location:
Calculated MW:
Observed MW:15KD/20kDa
Anti-RGCC Antibody (CAB17689)Western blot - RGCC Polyclonal Antibody (CAB17689)
Synonyms:C13orf15, RGC-32, RGC32, bA157L14.2, RGCC
Background:This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
UniProt Protein Function:RGC32: modulates the activity of cell cycle-specific kinases. Interacts with CDK1 and PLK1. Enhances CDK1 activity and contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. Interacts with SMAD3. Cytoplasmic in unstimulated cells; translocates to the nucleus following activation by complement. Associated with the centrosome during prometaphase and metaphase. Induced by Epstein-Barr virus (EBV). Up-regulated in aorta endothelial cells in response to complement activation. Important in vascular smooth muscle cell (VSMC) differentiation following transforming growth factor-beta (TGF-beta) induction. Its expression is greatly induced by TGF-beta in neural crest cells, leading to the induction of VSMC gene promoters. Smad and RhoA signaling are important for RGC-32 activation in neural crest cells. Forms a complex with hnRNP A/B that regulates the transcription of VSMC differentiation genes. Two isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit; Cell cycle regulation

Chromosomal Location of Human Ortholog: 13q14.11

Cellular Component: centrosome; cytoplasm; nucleus

Molecular Function:protein binding; protein kinase activator activity; protein kinase binding

Biological Process: positive regulation of mitosis; positive regulation of collagen biosynthetic process; negative regulation of cytokine secretion; negative regulation of blood vessel endothelial cell migration; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; complement activation; negative regulation of cell proliferation; negative regulation of angiogenesis; negative regulation of exit from mitosis; positive regulation of stress fiber formation; negative regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of cytokine secretion

NCBI Summary:This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H4X1
NCBI GenInfo Identifier:132626811
NCBI Gene ID:28984
NCBI Accession:NP_054778.2
UniProt Secondary Accession:Q9H4X1,Q6NZ48, Q9UL69,
UniProt Related Accession:Q9H4X1
Molecular Weight:12,924 Da
NCBI Full Name:regulator of cell cycle RGCC
NCBI Synonym Full Names:regulator of cell cycle
NCBI Official Symbol:RGCC  
NCBI Official Synonym Symbols:RGC32; RGC-32; C13orf15; bA157L14.2  
NCBI Protein Information:regulator of cell cycle RGCC
UniProt Protein Name:Regulator of cell cycle RGCC
UniProt Synonym Protein Names:Response gene to complement 32 protein; RGC-32
Protein Family:Regulator of cell cycle
UniProt Gene Name:RGCC  
UniProt Entry Name:RGCC_HUMAN
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