Cell Biology Antibodies 10
Anti-RDM1 Antibody (CAB6845)
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- SKU:
- CAB6845
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-RDM1 Antibody |
| Antibody SKU: | CAB6845 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 125-284 of human RDM1 (NP_663629.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney, Mouse heart, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 125-284 of human RDM1 (NP_663629.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NGCS KRII KLQE LSDL EERE NEDS MVPL PKQS LKFF CALE VVLP SCDC RSPG IGLV EEPM DKVE EGPL SFLM KRKT AQKL AIQK ALSD AFQK LLIV VLES GKIA VEYR PSED IVGV RCEE ELHG LIQV PCSP WKQY GQEE EGYL SDFS LEEE EFRL PELD |
| Gene ID: | 201299 |
| Uniprot: | Q8NG50 |
| Cellular Location: | Cajal body, Cytoplasm, Nucleus, PML body, nucleolus |
| Calculated MW: | 8kDa/12-31kDa |
| Observed MW: | 32kDa |
| Synonyms: | RDM1, RAD52B |
| Background: | This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. |
| UniProt Protein Function: | RDM1: May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA. 11 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: Cajal body; PML body; cytoplasm; nucleolus Molecular Function:DNA binding; RNA binding; nucleotide binding Biological Process: DNA repair; DNA recombination |
| NCBI Summary: | This gene encodes a protein involved in the cellular response to cisplatin, a drug commonly used in chemotherapy. The protein encoded by this gene contains two motifs: a motif found in RAD52, a protein that functions in DNA double-strand breaks and homologous recombination, and an RNA recognition motif (RRM) that is not found in RAD52. The RAD52 motif region in RAD52 is important for protein function and may be involved in DNA binding or oligomerization. Alternatively spliced transcript variants encoding different isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NG50 |
| NCBI GenInfo Identifier: | 74762574 |
| NCBI Gene ID: | 201299 |
| NCBI Accession: | Q8NG50.1 |
| UniProt Secondary Accession: | Q8NG50,A0JP55, A8MV46, A8MY68, A8MZ92, A8RCS5, A8RCT0 A8RCT5, A8RCT8, A8RCU3, A8RCU8, A8RCW0, |
| UniProt Related Accession: | Q8NG50 |
| Molecular Weight: | 284 |
| NCBI Full Name: | RAD52 motif-containing protein 1 |
| NCBI Synonym Full Names: | RAD52 motif containing 1 |
| NCBI Official Symbol: | RDM1 |
| NCBI Official Synonym Symbols: | RAD52B |
| NCBI Protein Information: | RAD52 motif-containing protein 1; RAD52 motif 1; RAD52 homolog B |
| UniProt Protein Name: | RAD52 motif-containing protein 1 |
| UniProt Synonym Protein Names: | RAD52 homolog B |
| Protein Family: | RAD52 motif-containing protein |
| UniProt Gene Name: | RDM1 |
| UniProt Entry Name: | RDM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RDM1 antibody (CAB6845) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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