Developmental Biology
Anti-RBM4 Antibody (CAB10362)
- SKU:
- CAB10362
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-RBM4 Antibody |
| Antibody SKU: | CAB10362 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human RBM4 (NP_002887.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human RBM4 (NP_002887.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVKL FIGN LPRE ATEQ EIRS LFEQ YGKV LECD IIKN YGFV HIED KTAA EDAI RNLH HYKL HGVN INVE ASKN KSKT STKL HVGN ISPT CTNK ELRA KFEE YGPV IECD IVKD YAFV HMER AEDA VEAI RGLD NTEF QGKR |
| Gene ID: | 5936 |
| Uniprot: | Q9BWF3 |
| Cellular Location: | Cytoplasm, Cytoplasmic granule, Nucleus, Nucleus speckle, nucleolus |
| Calculated MW: | 16kDa/19kDa/20kDa/40kDa |
| Observed MW: | Refer to figures |
| Synonyms: | RBM4, LARK, RBM4A, ZCCHC21, ZCRB3A |
| Background: |
| UniProt Protein Function: | RBM4: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of EIF2C2- containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; Nucleolus; RNA splicing; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 11q13 Cellular Component: nucleoplasm; stress granule; cytoplasm; nucleolus; nuclear speck; nucleus Molecular Function:mRNA binding; protein binding; miRNA binding; mRNA 3'-UTR binding; zinc ion binding; RNA binding; nucleotide binding Biological Process: negative regulation of translational initiation; RNA splicing; response to arsenic; stress-activated MAPK cascade; miRNA-mediated gene silencing, negative regulation of translation; entrainment of circadian clock by photoperiod; RNA processing; negative regulation of translation in response to stress; regulation of nucleocytoplasmic transport; negative regulation of translation; positive regulation of muscle cell differentiation; cell differentiation; mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome |
| UniProt Code: | Q9BWF3 |
| NCBI GenInfo Identifier: | 62511089 |
| NCBI Gene ID: | 5936 |
| NCBI Accession: | Q9BWF3.1 |
| UniProt Related Accession: | Q9BWF3 |
| Molecular Weight: | 40 kDa |
| NCBI Full Name: | RNA-binding protein 4 |
| NCBI Synonym Full Names: | RNA binding motif protein 4 |
| NCBI Official Symbol: | RBM4 |
| NCBI Official Synonym Symbols: | LARK; RBM4A; ZCRB3A; ZCCHC21 |
| NCBI Protein Information: | RNA-binding protein 4 |
| UniProt Protein Name: | RNA-binding protein 4 |
| UniProt Synonym Protein Names: | Lark homolog; hLark; RNA-binding motif protein 4; RNA-binding motif protein 4a |
| Protein Family: | RNA-binding protein |
| UniProt Gene Name: | RBM4 |
| UniProt Entry Name: | RBM4_HUMAN |
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