Anti-RALBP1 Antibody (CAB9701)

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SKU:
CAB9701
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RIP1
Synonyms:
RLIP1
Synonyms:
RLIP76

Description

Product Name:RALBP1 Rabbit mAb
Product Code:CAB9701
Size:20uL, 50uL, 100uL
Synonyms:RIP1, RLIP1, RLIP76
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human RALBP1
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:THP-1, C6
Immunogen:A synthesized peptide derived from human RALBP1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10928
Uniprot:Q15311
Calculated MW:95kDa
Observed MW:95kDa
UniProt Protein Function:RALBP1: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis. Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
UniProt Protein Details:

Protein type:GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 18p11.3

Cellular Component: membrane; cytosol

Molecular Function:protein binding; ATPase activity, coupled to movement of substances; ATPase activity; Rac GTPase binding; Ral GTPase binding; GTPase activator activity

Biological Process: regulation of GTPase activity; regulation of small GTPase mediated signal transduction; metabolic process; transport; small GTPase mediated signal transduction; chemotaxis; signal transduction

NCBI Summary:RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
UniProt Code:Q15311
NCBI GenInfo Identifier:34098413
NCBI Gene ID:10928
NCBI Accession:Q15311.3
UniProt Related Accession:Q15311
Molecular Weight:
NCBI Full Name:RalA-binding protein 1
NCBI Synonym Full Names:ralA binding protein 1
NCBI Official Symbol:RALBP1  
NCBI Official Synonym Symbols:RIP1; RLIP1; RLIP76  
NCBI Protein Information:ralA-binding protein 1
UniProt Protein Name:RalA-binding protein 1
UniProt Synonym Protein Names:76 kDa Ral-interacting protein; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1
Protein Family:RNA-binding protein
UniProt Gene Name:RALBP1  
UniProt Entry Name:RBP1_HUMAN
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