Cell Biology Antibodies 5

Anti-QSOX2 Antibody (CAB15214)

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SKU:
CAB15214
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-QSOX2 Antibody
Antibody SKU:CAB15214
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 370-650 of human QSOX2 (NP_859052.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse pancreas, Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 370-650 of human QSOX2 (NP_859052.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VKKL LEML QEWL ASLP LDRI PYNA VLDL VNNK MRIS GIFL TNHI KWVG CQGS RSEL RGYP CSLW KLFH TLTV EAST HPDA LVGT GFED DPQA VLQT MRRY VHTF FGCK ECGE HFEE MAKE SMDS VKTP DQAI LWLW KKHN MVNG RLAG HLSE DPRF PKLQ WPTP DLCP ACHE EIKG LASW DEGH VLTF LKQH YGRD NLLD TYSA DQGD SSEG GTLA RGEE EEKR LTPP EVSH GDRD TQSV RPPG ALGP RPAL PESL HHSL DGKL QSLD GPGA HKEV GGAA P
Gene ID:169714
Uniprot:Q6ZRP7
Cellular Location:Cell membrane, Membrane, Nucleus membrane, Secreted, Single-pass membrane protein
Calculated MW:77kDa
Observed MW:85kDa
Synonyms:QSOX2, QSCN6L1, SOXN
Background:
UniProt Protein Function:QSCN6L1: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
UniProt Protein Details:

Protein type:Apoptosis; Membrane protein, integral; EC 1.8.3.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: nuclear membrane; extracellular region; integral to membrane; plasma membrane

Molecular Function:thiol oxidase activity

Biological Process: cell redox homeostasis

NCBI Summary:QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, Jun 2009]
UniProt Code:Q6ZRP7
NCBI GenInfo Identifier:145580631
NCBI Gene ID:169714
NCBI Accession:NP_859052.3
UniProt Secondary Accession:Q6ZRP7,Q5TB37, Q7Z7B6, Q86VV7, Q8N3G2, A2CEE0, A6NLB0
UniProt Related Accession:Q6ZRP7
Molecular Weight:77,529 Da
NCBI Full Name:sulfhydryl oxidase 2
NCBI Synonym Full Names:quiescin Q6 sulfhydryl oxidase 2
NCBI Official Symbol:QSOX2  
NCBI Official Synonym Symbols:SOXN; QSCN6L1  
NCBI Protein Information:sulfhydryl oxidase 2; quiescin Q6-like 1; quiescin Q6-like protein 1; neuroblastoma-derived sulfhydryl oxidase
UniProt Protein Name:Sulfhydryl oxidase 2
UniProt Synonym Protein Names:Neuroblastoma-derived sulfhydryl oxidase; Quiescin Q6-like protein 1
Protein Family:Sulfhydryl oxidase
UniProt Gene Name:QSOX2  
UniProt Entry Name:QSOX2_HUMAN
Anti-QSOX2 Antibody (CAB15214)Western blot analysis of extracts of various cell lines, using QSOX2 antibody (CAB15214) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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