Metabolism Antibodies 2

Anti-PTGDS Antibody (CAB1889)

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SKU:
CAB1889
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-PTGDS Antibody
Antibody SKU:CAB1889
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-190 of human PTGDS (NP_000945.3).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 23-190 of human PTGDS (NP_000945.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:APEA QVSV QPNF QQDK FLGR WFSA GLAS NSSW LREK KAAL SMCK SVVA PATD GGLN LTST FLRK NQCE TRTM LLQP AGSL GSYS YRSP HWGS TYSV SVVE TDYD QYAL LYSQ GSKG PGED FRMA TLYS RTQT PRAE LKEK FTAF CKAQ GFTE DTIV FLPQ TDKC MTEQ
Gene ID:5730
Uniprot:P41222
Cellular Location:Cytoplasm, Golgi apparatus, Nucleus membrane, Rough endoplasmic reticulum, Secreted, perinuclear region
Calculated MW:21kDa
Observed MW:33kDa
Synonyms:PTGDS, L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2
Background:The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.
UniProt Protein Function:PTGDS: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Belongs to the calycin superfamily. Lipocalin family.
UniProt Protein Details:

Protein type:EC 5.3.99.2; Secreted; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Secreted, signal peptide; Isomerase

Chromosomal Location of Human Ortholog: 9q34.2-q34.3

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; nuclear membrane; rough endoplasmic reticulum; perinuclear region of cytoplasm; extracellular region

Molecular Function:retinoid binding; prostaglandin-D synthase activity; transporter activity; fatty acid binding

Biological Process: transport; cyclooxygenase pathway; response to glucocorticoid stimulus; arachidonic acid metabolic process; prostaglandin biosynthetic process; regulation of circadian sleep/wake cycle, sleep

NCBI Summary:The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
UniProt Code:P41222
NCBI GenInfo Identifier:730305
NCBI Gene ID:5730
NCBI Accession:P41222.1
UniProt Secondary Accession:P41222,Q5SQ10, Q7M4P3, Q9UC22, Q9UCC9, Q9UCD9, B2R727
UniProt Related Accession:P41222
Molecular Weight:21kDa
NCBI Full Name:Prostaglandin-H2 D-isomerase
NCBI Synonym Full Names:prostaglandin D2 synthase 21kDa (brain)
NCBI Official Symbol:PTGDS  
NCBI Official Synonym Symbols:PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS  
NCBI Protein Information:prostaglandin-H2 D-isomerase; cerebrin-28; PGD2 synthase; beta-trace protein; prostaglandin D synthase; prostaglandin-D2 synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase
UniProt Protein Name:Prostaglandin-H2 D-isomerase
UniProt Synonym Protein Names:Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; Lipocalin-type prostaglandin-D synthase; Prostaglandin-D2 synthase; PGD2 synthase; PGDS; PGDS2
Protein Family:Prostaglandin-H2 D-isomerase
UniProt Gene Name:PTGDS  
UniProt Entry Name:PTGDS_HUMAN
Anti-PTGDS Antibody (CAB1889)Western blot analysis of extracts of mouse heart, using PTGDS antibody (CAB1889) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-PTGDS Antibody (CAB1889)Immunohistochemistry of paraffin-embedded rat brain using PTGDS antibody (CAB1889) at dilution of 1:200 (40x lens).
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