| UniProt Protein Function: | PSMD3: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the proteasome subunit S3 family. |
| UniProt Protein Details: | Protein type:Protease; Proteasome complex Chromosomal Location of Human Ortholog: 17q21.1 Cellular Component: proteasome complex; nucleoplasm; membrane; cytoplasm; nucleus; cytosol Molecular Function:enzyme regulator activity Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis |
| NCBI Summary: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012] |
| UniProt Code: | O43242 |
| NCBI GenInfo Identifier: | 20532405 |
| NCBI Gene ID: | 5709 |
| NCBI Accession: | O43242.2 |
| UniProt Secondary Accession: | O43242,Q96EI2, Q9BQA4, B3KMW9, B4DT72, |
| UniProt Related Accession: | O43242 |
| Molecular Weight: | 534 |
| NCBI Full Name: | 26S proteasome non-ATPase regulatory subunit 3 |
| NCBI Synonym Full Names: | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 |
| NCBI Official Symbol: | PSMD3 |
| NCBI Official Synonym Symbols: | S3; P58; RPN3; TSTA2 |
| NCBI Protein Information: | 26S proteasome non-ATPase regulatory subunit 3; proteasome subunit p58; 26S proteasome regulatory subunit S3; 26S proteasome regulatory subunit RPN3; tissue specific transplantation antigen 2 |
| UniProt Protein Name: | 26S proteasome non-ATPase regulatory subunit 3 |
| UniProt Synonym Protein Names: | 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; Proteasome subunit p58 |
| Protein Family: | 26S proteasome non-ATPase regulatory |
| UniProt Gene Name: | PSMD3 |
| UniProt Entry Name: | PSMD3_HUMAN |
