Developmental Biology

Anti-PSMA8 Antibody (CAB14365)

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SKU:
CAB14365
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-PSMA8 Antibody
Antibody SKU:CAB14365
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PSMA8 (NP_653263.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:K-562, Mouse thymus, Mouse testis, Rat thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PSMA8 (NP_653263.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASR YDRA ITVF SPDG HLFQ VEYA QEAV KKGS TAVG IRGT NIVV LGVE KKSV AKLQ DERT VRKI CALD DHVC MAFA VLTI FIGL TADA RVVI NRAR VECQ SHKL TVED PVTV EYIT RFIA TLKQ KYTQ SNGR RPFG ISAL IVGF DDDG ISRL YQTD PSGT YHAW KANA IGRS AKTV REFL EKNY TEDA IASD SEAI KLAI KALL EVVQ SGGK NIEL AIIR RNQP LKMF SAKE VELY VTEI
Gene ID:143471
Uniprot:Q8TAA3
Cellular Location:Cytoplasm, Nucleus
Calculated MW:23kDa/27kDa/28kDa
Observed MW:28kDa
Synonyms:PSMA8, PSMA7L
Background:
UniProt Protein Function:Function: Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH
UniProt Protein Details:

By similarity.

Catalytic activity: Cleavage of peptide bonds with very broad specificity.

Subunit structure: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel

By similarity. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity.

Sequence similarities: Belongs to the peptidase T1A family.

UniProt Code:Q8TAA3
NCBI GenInfo Identifier:68303565
NCBI Gene ID:143471
NCBI Accession:NP_001020268.1
UniProt Secondary Accession:Q8TAA3,Q8IVP4, Q8TA98, Q8TAA2, B0YJ75,
UniProt Related Accession:Q8TAA3
Molecular Weight:28,530 Da
NCBI Full Name:proteasome subunit alpha type-7-like isoform 3
NCBI Synonym Full Names:proteasome (prosome, macropain) subunit, alpha type, 8
NCBI Official Symbol:PSMA8  
NCBI Official Synonym Symbols:PSMA7L  
NCBI Protein Information:proteasome subunit alpha type-7-like
UniProt Protein Name:Proteasome subunit alpha type-7-like
Protein Family:Proteasome
UniProt Gene Name:PSMA8  
UniProt Entry Name:PSA7L_HUMAN
Anti-PSMA8 Antibody (CAB14365)Western blot analysis of extracts of various cell lines, using PSMA8 antibody (CAB14365) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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