Anti-PSMA/FOLH1 Antibody (CAB9547)

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SKU:
CAB9547
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
FGCP
Synonyms:
FOLH
Synonyms:
GCP2
Synonyms:
GCPII
Synonyms:
NAALAD1
Synonyms:
NAALAdase
Synonyms:
PSM
Synonyms:
PSMA
Synonyms:
mGCP
Research Area:
Cell Biology

Description

Product Name:PSMA/FOLH1 Rabbit mAb
Product Code:CAB9547
Size:20uL, 50uL, 100uL
Synonyms:FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP
Applications:WB, IF
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PSMA/FOLH1
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:LNCaP
Immunogen:A synthesized peptide derived from human PSMA/FOLH1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2346
Uniprot:Q04609
Calculated MW:110kDa
Observed MW:100KDa
UniProt Protein Function:FOLH1: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Belongs to the peptidase M28 family. M28B subfamily. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; EC 3.4.17.21; Protease

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: membrane; integral to plasma membrane; cytoplasm

Molecular Function:peptidase activity; dipeptidase activity; metallopeptidase activity; carboxypeptidase activity; metal ion binding

Biological Process: folic acid and derivative metabolic process; proteolysis

NCBI Summary:This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
UniProt Code:Q04609
NCBI GenInfo Identifier:548615
NCBI Gene ID:2346
NCBI Accession:Q04609.1
UniProt Secondary Accession:Q04609,O43748, Q16305, Q541A4, Q8TAY3, Q9NP15, A4UU12 A9CB79, B7Z312, B7Z343, D3DQS5, E9PDX8,
UniProt Related Accession:Q04609
Molecular Weight:84kDa
NCBI Full Name:Glutamate carboxypeptidase 2
NCBI Synonym Full Names:folate hydrolase (prostate-specific membrane antigen) 1
NCBI Official Symbol:FOLH1  
NCBI Official Synonym Symbols:PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase  
NCBI Protein Information:glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen
UniProt Protein Name:Glutamate carboxypeptidase 2
UniProt Synonym Protein Names:Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; PSM; PSMA; Pteroylpoly-gamma-glutamate carboxypeptidase
UniProt Gene Name:FOLH1  
UniProt Entry Name:FOLH1_HUMAN
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