Anti-PSD93/chapsyn-110/DLG2 Antibody (CAB19669)
- SKU:
- CAB19669
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PPP1R58
- Synonyms:
- PSD-93
- Synonyms:
- PSD93
- Synonyms:
- chapsyn-110
Description
| Product Name: | PSD93/chapsyn-110/DLG2 Rabbit mAb |
| Product Code: | CAB19669 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PPP1R58, PSD-93, PSD93, chapsyn-110 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PSD93/chapsyn-110/DLG2 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, C6, SH-SY5Y, U-251MG, Mouse lung, Mouse spinal cord, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human PSD93/chapsyn-110/DLG2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1740 |
| Uniprot: | Q15700 |
| Calculated MW: | 110kDa |
| Observed MW: | 110KDa |
| UniProt Protein Function: | PSD-93: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11q14.1 Cellular Component: basolateral plasma membrane; ionotropic glutamate receptor complex; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; voltage-gated potassium channel complex Molecular Function:guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; protein binding Biological Process: establishment and/or maintenance of epithelial cell polarity; nervous system development; receptor clustering; synaptic transmission |
| NCBI Summary: | This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008] |
| UniProt Code: | Q15700 |
| NCBI GenInfo Identifier: | 215274165 |
| NCBI Gene ID: | 1740 |
| NCBI Accession: | Q15700.3 |
| UniProt Secondary Accession: | Q15700,Q59G57, Q5H9Q4, Q68CQ8, Q6ZTA8, B7WNY8, F8W9V6 |
| UniProt Related Accession: | Q15700 |
| Molecular Weight: | 38,404 Da |
| NCBI Full Name: | Disks large homolog 2 |
| NCBI Synonym Full Names: | discs large MAGUK scaffold protein 2 |
| NCBI Official Symbol: | DLG2 |
| NCBI Official Synonym Symbols: | PSD93; PSD-93; PPP1R58; chapsyn-110 |
| NCBI Protein Information: | disks large homolog 2 |
| UniProt Protein Name: | Disks large homolog 2 |
| UniProt Synonym Protein Names: | Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93 |
| Protein Family: | Disks large |
| UniProt Gene Name: | DLG2 |
| UniProt Entry Name: | DLG2_HUMAN |
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