Anti-PSD93/chapsyn-110/DLG2 Antibody (CAB19669)

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SKU:
CAB19669
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PPP1R58
Synonyms:
PSD-93
Synonyms:
PSD93
Synonyms:
chapsyn-110

Description

Product Name:PSD93/chapsyn-110/DLG2 Rabbit mAb
Product Code:CAB19669
Size:20uL, 50uL, 100uL
Synonyms:PPP1R58, PSD-93, PSD93, chapsyn-110
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PSD93/chapsyn-110/DLG2
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, C6, SH-SY5Y, U-251MG, Mouse lung, Mouse spinal cord, Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human PSD93/chapsyn-110/DLG2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1740
Uniprot:Q15700
Calculated MW:110kDa
Observed MW:110KDa
UniProt Protein Function:PSD-93: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q14.1

Cellular Component: basolateral plasma membrane; ionotropic glutamate receptor complex; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; voltage-gated potassium channel complex

Molecular Function:guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; protein binding

Biological Process: establishment and/or maintenance of epithelial cell polarity; nervous system development; receptor clustering; synaptic transmission

NCBI Summary:This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
UniProt Code:Q15700
NCBI GenInfo Identifier:215274165
NCBI Gene ID:1740
NCBI Accession:Q15700.3
UniProt Secondary Accession:Q15700,Q59G57, Q5H9Q4, Q68CQ8, Q6ZTA8, B7WNY8, F8W9V6
UniProt Related Accession:Q15700
Molecular Weight:38,404 Da
NCBI Full Name:Disks large homolog 2
NCBI Synonym Full Names:discs large MAGUK scaffold protein 2
NCBI Official Symbol:DLG2  
NCBI Official Synonym Symbols:PSD93; PSD-93; PPP1R58; chapsyn-110  
NCBI Protein Information:disks large homolog 2
UniProt Protein Name:Disks large homolog 2
UniProt Synonym Protein Names:Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93
Protein Family:Disks large
UniProt Gene Name:DLG2  
UniProt Entry Name:DLG2_HUMAN
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