Epigenetics & Nuclear Signaling Antibodies 1
Anti-PRPS2 Antibody (CAB12644)
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- SKU:
- CAB12644
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-PRPS2 Antibody |
| Antibody SKU: | CAB12644 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PRPS2 (NP_002756.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, MCF7, Mouse brain, Mouse heart, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PRPS2 (NP_002756.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPNI VLFS GSSH QDLS QRVA DRLG LELG KVVT KKFS NQET SVEI GESV RGED VYII QSGC GEIN DNLM ELLI MINA CKIA SSSR VTAV IPCF PYAR QDKK DKSR APIS AKLV ANML SVAG ADHI ITMD LHAS QIQG FFDI PVDN LYAE PAVL QWIR ENIA EWKN CIIV SPDA GGAK RVTS IADR LNVE FALI HKER KKAN EVDR MVLV GDVK DRVA ILVD DMAD TCGT ICHA ADKL LSAG |
| Gene ID: | 5634 |
| Uniprot: | P11908 |
| Cellular Location: | |
| Calculated MW: | 34kDa/35kDa |
| Observed MW: | 35kDa |
| Synonyms: | PRPS2, PRSII |
| Background: | This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | PRPS2: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Belongs to the ribose-phosphate pyrophosphokinase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, other; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: Xp22.2 Molecular Function:ATP binding; identical protein binding; protein binding; protein homodimerization activity; ribose phosphate diphosphokinase activity Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| NCBI Summary: | This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
| UniProt Code: | P11908 |
| NCBI GenInfo Identifier: | 125583 |
| NCBI Gene ID: | 5634 |
| NCBI Accession: | P11908.2 |
| UniProt Secondary Accession: | P11908,Q0VDH9, Q0VDI0, Q15245, Q2TAK7, |
| UniProt Related Accession: | P11908 |
| Molecular Weight: | 35,054 Da |
| NCBI Full Name: | Ribose-phosphate pyrophosphokinase 2 |
| NCBI Synonym Full Names: | phosphoribosyl pyrophosphate synthetase 2 |
| NCBI Official Symbol: | PRPS2 |
| NCBI Official Synonym Symbols: | PRSII |
| NCBI Protein Information: | ribose-phosphate pyrophosphokinase 2 |
| UniProt Protein Name: | Ribose-phosphate pyrophosphokinase 2 |
| UniProt Synonym Protein Names: | PPRibP; Phosphoribosyl pyrophosphate synthase II; PRS-II |
| UniProt Gene Name: | PRPS2 |
| UniProt Entry Name: | PRPS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PRPS2 antibody (CAB12644) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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