Epigenetics & Nuclear Signaling Antibodies 5
Anti-PRPF8 Antibody (CAB4575)
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- SKU:
- CAB4575
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HPRP8
- Synonyms:
- PRP8
- Synonyms:
- PRPC8
- Synonyms:
- RP13
- Synonyms:
- SNRNP220
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | PRPF8 Rabbit mAb |
| Product Code: | CAB4575 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HPRP8, PRP8, PRPC8, RP13, SNRNP220 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PRPF8 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, Jurkat, Mouse brain, Mouse spleen |
| Immunogen: | A synthesized peptide derived from human PRPF8 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10594 |
| Uniprot: | Q6P2Q9 |
| Calculated MW: | 274kDa |
| Observed MW: | 274KDa |
| UniProt Protein Function: | Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. |
| NCBI Summary: | Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6P2Q9 |
| NCBI GenInfo Identifier: | 67460824 |
| NCBI Gene ID: | 10594 |
| NCBI Accession: | Q6P2Q9.2 |
| UniProt Related Accession: | Q6P2Q9 |
| Molecular Weight: | |
| NCBI Full Name: | Pre-mRNA-processing-splicing factor 8 |
| NCBI Synonym Full Names: | pre-mRNA processing factor 8 |
| NCBI Official Symbol: | PRPF8 |
| NCBI Official Synonym Symbols: | PRP8; RP13; HPRP8; PRPC8; SNRNP220 |
| NCBI Protein Information: | pre-mRNA-processing-splicing factor 8 |
| UniProt Protein Name: | Pre-mRNA-processing-splicing factor 8 |
| UniProt Synonym Protein Names: | 220 kDa U5 snRNP-specific protein; PRP8 homolog; Splicing factor Prp8; p220 |
| Protein Family: | Pre-mRNA-splicing factor |
| UniProt Gene Name: | PRPF8 |
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