Anti-PRP19 Antibody (CAB9660)
- SKU:
- CAB9660
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NMP200
- Synonyms:
- PRP19
- Synonyms:
- PSO4
- Synonyms:
- SNEV
- Synonyms:
- UBOX4
- Synonyms:
- hPSO4
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | PRP19 Rabbit mAb |
| Product Code: | CAB9660 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PRP19 |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, SKOV3, Mouse thymus, Rat spleen |
| Immunogen: | A synthesized peptide derived from human PRP19 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 27339 |
| Uniprot: | Q9UMS4 |
| Calculated MW: | 55kDa |
| Observed MW: | 55kDa |
| UniProt Protein Function: | PRPF19: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Belongs to the WD repeat PRP19 family. |
| UniProt Protein Details: | Protein type:RNA splicing; Spliceosome; Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19 Chromosomal Location of Human Ortholog: 11q12.2 Cellular Component: nucleoplasm; DNA replication factor A complex; membrane; cytoplasm; lipid particle; spindle; nuclear speck; nucleus Molecular Function:identical protein binding; protein binding; ligase activity Biological Process: nuclear mRNA splicing, via spliceosome; assembly of spliceosomal tri-snRNP; proteasomal protein catabolic process; positive regulation of nuclear mRNA splicing, via spliceosome; negative regulation of neuron differentiation; protein polyubiquitination; RNA splicing; lipid biosynthetic process; spliceosome assembly; gene expression; inner cell mass cell proliferation; generation of catalytic spliceosome for first transesterification step; double-strand break repair via nonhomologous end joining; positive regulation of astrocyte differentiation |
| NCBI Summary: | PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008] |
| UniProt Code: | Q9UMS4 |
| NCBI GenInfo Identifier: | 55976619 |
| NCBI Gene ID: | 27339 |
| NCBI Accession: | Q9UMS4.1 |
| UniProt Related Accession: | Q9UMS4 |
| Molecular Weight: | 504 |
| NCBI Full Name: | Pre-mRNA-processing factor 19 |
| NCBI Synonym Full Names: | pre-mRNA processing factor 19 |
| NCBI Official Symbol: | PRPF19 |
| NCBI Official Synonym Symbols: | PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200 |
| NCBI Protein Information: | pre-mRNA-processing factor 19; psoralen 4; PRP19/PSO4 homolog; senescence evasion factor; nuclear matrix protein 200; PRP19/PSO4 pre-mRNA processing factor 19 homolog; nuclear matrix protein NMP200 related to splicing factor PRP19 |
| UniProt Protein Name: | Pre-mRNA-processing factor 19 |
| UniProt Synonym Protein Names: | Nuclear matrix protein 200; PRP19/PSO4 homolog; Senescence evasion factor |
| UniProt Gene Name: | PRPF19 |
| UniProt Entry Name: | PRP19_HUMAN |
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