Anti-PRP19 Antibody (CAB9660)

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SKU:
CAB9660
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NMP200
Synonyms:
PRP19
Synonyms:
PSO4
Synonyms:
SNEV
Synonyms:
UBOX4
Synonyms:
hPSO4
Research Area:
Epigenetics and Nuclear Signaling

Description

Product Name:PRP19 Rabbit mAb
Product Code:CAB9660
Size:20uL, 50uL, 100uL
Synonyms:NMP200, PRP19, PSO4, SNEV, UBOX4, hPSO4
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PRP19
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, SKOV3, Mouse thymus, Rat spleen
Immunogen:A synthesized peptide derived from human PRP19
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:27339
Uniprot:Q9UMS4
Calculated MW:55kDa
Observed MW:55kDa
UniProt Protein Function:PRPF19: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Belongs to the WD repeat PRP19 family.
UniProt Protein Details:

Protein type:RNA splicing; Spliceosome; Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: nucleoplasm; DNA replication factor A complex; membrane; cytoplasm; lipid particle; spindle; nuclear speck; nucleus

Molecular Function:identical protein binding; protein binding; ligase activity

Biological Process: nuclear mRNA splicing, via spliceosome; assembly of spliceosomal tri-snRNP; proteasomal protein catabolic process; positive regulation of nuclear mRNA splicing, via spliceosome; negative regulation of neuron differentiation; protein polyubiquitination; RNA splicing; lipid biosynthetic process; spliceosome assembly; gene expression; inner cell mass cell proliferation; generation of catalytic spliceosome for first transesterification step; double-strand break repair via nonhomologous end joining; positive regulation of astrocyte differentiation

NCBI Summary:PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]
UniProt Code:Q9UMS4
NCBI GenInfo Identifier:55976619
NCBI Gene ID:27339
NCBI Accession:Q9UMS4.1
UniProt Related Accession:Q9UMS4
Molecular Weight:504
NCBI Full Name:Pre-mRNA-processing factor 19
NCBI Synonym Full Names:pre-mRNA processing factor 19
NCBI Official Symbol:PRPF19  
NCBI Official Synonym Symbols:PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200  
NCBI Protein Information:pre-mRNA-processing factor 19; psoralen 4; PRP19/PSO4 homolog; senescence evasion factor; nuclear matrix protein 200; PRP19/PSO4 pre-mRNA processing factor 19 homolog; nuclear matrix protein NMP200 related to splicing factor PRP19
UniProt Protein Name:Pre-mRNA-processing factor 19
UniProt Synonym Protein Names:Nuclear matrix protein 200; PRP19/PSO4 homolog; Senescence evasion factor
UniProt Gene Name:PRPF19  
UniProt Entry Name:PRP19_HUMAN
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