Epigenetics & Nuclear Signaling Antibodies 4
Anti-Protein polybromo-1 Antibody (CAB9878)
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- SKU:
- CAB9878
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-Protein polybromo-1 Antibody |
| Antibody SKU: | CAB9878 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PBRM1 (NP_060783.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, BT-474, NIH/3T3, LO2, Mouse lung, Mouse thymus, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PBRM1 (NP_060783.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGSK RRRA TSPS SSVS GDFD DGHH SVST PGPS RKRR RLSN LPTV DPIA VCHE LYNT IRDY KDEQ GRLL CELF IRAP KRRN QPDY YEVV SQPI DLMK IQQK LKME EYDD VNLL TADF QLLF NNAK SYYK PDSP EYKA ACKL WDLY LRTR NEFV QKGE ADDE DDDE DGQD NQGT VTEG SSPA YLKE ILEQ LLEA IVVA TNPS GRLI SELF QKLP SKVQ YPDY YAII KEPI DL |
| Gene ID: | 55193 |
| Uniprot: | Q86U86 |
| Cellular Location: | Nucleus |
| Calculated MW: | 99kDa/181-192kDa |
| Observed MW: | 230kDa |
| Synonyms: | PBRM1, BAF180, PB1 |
| Background: | This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. |
| UniProt Protein Function: | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation. |
| NCBI Summary: | This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q86U86 |
| NCBI GenInfo Identifier: | 73921624 |
| NCBI Gene ID: | 55193 |
| NCBI Accession: | Q86U86.1 |
| UniProt Secondary Accession: | Q86U86,Q1RMD1, Q1RMD2, Q96MS2, Q9H2T3, Q9H2T4, Q9H2T5 Q9H301, Q9H314, A1L381, A1L382, A4FUJ7, |
| UniProt Related Accession: | Q86U86 |
| Molecular Weight: | 184,043 Da |
| NCBI Full Name: | Protein polybromo-1 |
| NCBI Synonym Full Names: | polybromo 1 |
| NCBI Official Symbol: | PBRM1 |
| NCBI Official Synonym Symbols: | PB1; BAF180 |
| NCBI Protein Information: | protein polybromo-1 |
| UniProt Protein Name: | Protein polybromo-1 |
| UniProt Synonym Protein Names: | BRG1-associated factor 180; BAF180; Polybromo-1D |
| Protein Family: | Protein polybromo |
| UniProt Gene Name: | PBRM1 |
| UniProt Entry Name: | PB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PBRM1 antibody (CAB9878) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s. |
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