Autophagy Antibodies

Anti-Protein CLEC16A Antibody (CAB9753)

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SKU:
CAB9753
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Autophagy

Description

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Antibody Name:Anti-Protein CLEC16A Antibody
Antibody SKU:CAB9753
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 330-550 of human CLEC16A (NP_001230332.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human
Positive Samples:B cells, U-87MG, 293T, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 330-550 of human CLEC16A (NP_001230332.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SLAE VILN GDLS EMYA KTEQ DIQR SSAK PSIR CFIK PTET LERS LEMN KHKG KRRV QKRP NYKN VGEE EDEE KGPT EDAQ EDAE KAKE IEMV IMER SKLS ELAA STSV QEQN TTDE EKSA AATC SEST QWSR PFLD MVYH ALDS PDDD YHAL FVLC LLYA MSHN KGMD PEKL ERIQ LPVP NAAE KTTY NHPL AERL IRIM NNAA QPDG KIRL ATLE LSCL L
Gene ID:23274
Uniprot:Q2KHT3
Cellular Location:Endosome membrane, Lysosome membrane, Peripheral membrane protein
Calculated MW:14kDa/103kDa/117kDa
Observed MW:118kDa
Synonyms:CLEC16A, Gop-1, KIAA0350
Background:This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CLEC16A: Insulin-dependent diabetes mellitus is significantly associated with variation within a 233-kb linkage disequilibrium block on chromosome 16p13 that includes KIAA0350. Three common non-coding variants of KIAA0350 in strong linkage disequilibrium reach genome-wide significance for association with the disease (PubMed:17632545). Belongs to the CLEC16A/gop-1 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 16p13.13

Cellular Component: lysosomal membrane; endosome membrane

Biological Process: autophagy

NCBI Summary:This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Code:Q2KHT3
NCBI GenInfo Identifier:54792782
NCBI Gene ID:23274
NCBI Accession:NP_056041.1
UniProt Secondary Accession:Q2KHT3,O15058, Q6ZTB2,
UniProt Related Accession:Q2KHT3
Molecular Weight:14,283 Da
NCBI Full Name:protein CLEC16A isoform 1
NCBI Synonym Full Names:C-type lectin domain family 16 member A
NCBI Official Symbol:CLEC16A  
NCBI Official Synonym Symbols:Gop-1; KIAA0350  
NCBI Protein Information:protein CLEC16A
UniProt Protein Name:Protein CLEC16A
Protein Family:Protein
UniProt Gene Name:CLEC16A  
UniProt Entry Name:CL16A_HUMAN
Anti-Protein CLEC16A Polyclonal Antibody (CAB9753)Western blot analysis of extracts of various cell lines, using CLEC16A antibody (CAB9753) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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