Epigenetics & Nuclear Signaling Antibodies 5
Anti-PRMT6 Antibody (CAB5085)
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- SKU:
- CAB5085
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HRMT1L6
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | PRMT6 Rabbit mAb |
| Product Code: | CAB5085 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | HRMT1L6 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PRMT6 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, MCF7, NIH/3T3, Jurkat, Rat testis |
| Immunogen: | A synthesized peptide derived from human PRMT6 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55170 |
| Uniprot: | Q96LA8 |
| Calculated MW: | 42kDa |
| Observed MW: | 42KDa |
| UniProt Protein Function: | PRMT6: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). It thereby acts as a transcription corepressor of various genes such as HOXA2. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to stimulate the polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC). Belongs to the protein arginine N-methyltransferase family. PRMT6 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Methyltransferase; EC 2.1.1.125; Methyltransferase, protein arginine Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: nucleoplasm; nucleus; cytosol Molecular Function:histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; protein binding; histone binding Biological Process: histone methylation; establishment and/or maintenance of chromatin architecture; viral reproduction; transcription, DNA-dependent; base-excision repair; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q96LA8 |
| NCBI GenInfo Identifier: | 20137409 |
| NCBI Gene ID: | 55170 |
| NCBI Accession: | Q96LA8.1 |
| UniProt Related Accession: | Q96LA8 |
| Molecular Weight: | |
| NCBI Full Name: | Protein arginine N-methyltransferase 6 |
| NCBI Synonym Full Names: | protein arginine methyltransferase 6 |
| NCBI Official Symbol: | PRMT6 |
| NCBI Official Synonym Symbols: | HRMT1L6 |
| NCBI Protein Information: | protein arginine N-methyltransferase 6 |
| UniProt Protein Name: | Protein arginine N-methyltransferase 6 |
| UniProt Synonym Protein Names: | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6 (EC:2.1.1.125) |
| Protein Family: | Protein arginine N-methyltransferase |
| UniProt Gene Name: | PRMT6 |
| UniProt Entry Name: | ANM6_HUMAN |
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