Cell Biology Antibodies 4
Anti-PPP2R5B Antibody (CAB14252)
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- SKU:
- CAB14252
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PPP2R5B Antibody |
| Antibody SKU: | CAB14252 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human PPP2R5B (NP_006235.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human PPP2R5B (NP_006235.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | METK LPPA STPT SPSS PGLS PVPP PDKV DGFS RRSL RRAR PRRS HSSS QFRY QSNQ QELT PLPL LKDV PASE LHEL LSRK LAQC GVMF DFLD CVAD LKGK EVKR AALN ELVE CVGS TRGV LIEP VYPD II |
| Gene ID: | 5526 |
| Uniprot: | Q15173 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 57kDa |
| Observed MW: | 57kDa |
| Synonyms: | PPP2R5B, B56B, PR61B, B56beta |
| Background: | The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. |
| UniProt Protein Function: | PPP2R5B: a brain-specific, B regulatory subunit of the PP2A phosphoprotein phosphatase that modulates substrate selectivity, localization, and catalytic activity of the holoenzyme. Targeted by the KLHL15-Cul3 ubiquitin ligase complex, promoting its turnover by ubiquitylation and proteasomal degradation. Mediates dephosphorylation of tyrosine hydroxylase (TH) and calcium/calmodulin-dependent protein kinase type II (CaMK2). The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 pT308 and pS373. Belongs to the phosphatase 2A regulatory subunit B56 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 11q12 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding Biological Process: regulation of phosphoinositide 3-kinase cascade |
| NCBI Summary: | The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15173 |
| NCBI GenInfo Identifier: | 7387497 |
| NCBI Gene ID: | 5526 |
| NCBI Accession: | Q15173.1 |
| UniProt Secondary Accession: | Q15173,Q13853, |
| UniProt Related Accession: | Q15173 |
| Molecular Weight: | 57,294 Da |
| NCBI Full Name: | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform |
| NCBI Synonym Full Names: | protein phosphatase 2 regulatory subunit B'beta |
| NCBI Official Symbol: | PPP2R5B |
| NCBI Official Synonym Symbols: | B56B; PR61B |
| NCBI Protein Information: | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform |
| UniProt Synonym Protein Names: | PP2A B subunit isoform B'-beta; PP2A B subunit isoform B56-beta; PP2A B subunit isoform PR61-beta; PP2A B subunit isoform R5-beta |
| Protein Family: | Serine/threonine-protein phosphatase |
| UniProt Gene Name: | PPP2R5B |
| UniProt Entry Name: | 2A5B_HUMAN |
 | Western blot analysis of extracts of U-87MG cells, using PPP2R5B antibody (CAB14252) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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