Cell Biology Antibodies 7

Ser/thr-PP2A activator (PTPA) Rabbit Polyclonal Antibody (CAB1912)

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SKU:
CAB1912
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Polyclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
PP2A, PR53, PPP2R4, Ser/thr-PP2A activator (PTPA)
Research Use:
Cell Biology
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Description

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Ser/thr-PP2A activator (PTPA) Antibody (CAB1912)

The Ser/thr-PP2A activator (PTPA) Antibody (CAB1912) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the PPP2R4 protein, this antibody enables precise detection and analysis in different cell types, making it ideal for investigations in molecular biology and signal transduction pathways.PPP2R4 is known to play a crucial role in regulating cell growth, cell division, and cell death by modulating PP2A activity.

This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Ser/thr-PP2A activator (PTPA) Antibody
SKU:CAB1912
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MAEG ERQP PPDS SEEA PPAT QNFI IPKK EIHT VPDM GKWK RSQA YADY IGFI LTLN EGVK GKKL TFEY RVSE AIEK LVAL LNTL DRWI DETP PVDQ PSRF GNKA YRTW YAKL DEEA ENLV ATVV PTHL AAAV PEVA VYLK ESVG NSTR IDYG TGHE AAFA AFLC CLCK IGVL RVDD QIAI VFKV FNRY LEVM RKLQ KTYR MEPA GSQG VWGL DDFQ FLPF IWGS SQLI DHPY LEPR HFVD EKAV NENH KDYM FLEC ILFI TEMK TGPF AEHS NQLW NISA VPSW SKVN QGLI RMYK AECL EKFP VIQH FKFG SLLP IHPV TSG
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:
WB1:1000 - 1:6000
IF/ICC1:50 - 1:200
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:PP2A, PR53, PPP2R4, Ser/thr-PP2A activator (PTPA)
Positive Sample:Rat brain
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:41kDa
Observed MW:41kDa

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Purification MethodAffinity purification
Gene ID5524
RRIDAB_2763940
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Rat brain using Ser/thr-PP2A activator (PTPA) Rabbit pAb (CAB1912) at 1:1000 dilution incubated overnight at 4℃. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
Product ImageImmunofluorescence analysis of U2OS cells using Ser/thr-PP2A activator (PTPA) Rabbit pAb (CAB1912). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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