| UniProt Protein Function: | Spinophilin: actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain. |
| UniProt Protein Details: | Protein type:Protein phosphatase, regulatory subunit; Adaptor/scaffold Chromosomal Location of Human Ortholog: 17q21.33 Cellular Component: nucleoplasm; cortical actin cytoskeleton; adherens junction; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; protein phosphatase type 1 complex; filopodium Molecular Function:protein binding; protein phosphatase inhibitor activity; actin binding; protein phosphatase 1 binding Biological Process: regulation of synaptic transmission; regulation of protein amino acid phosphorylation; cell migration; regulation of cell growth by extracellular stimulus; filopodium formation; RNA splicing; regulation of exit from mitosis; calcium-mediated signaling; actin filament organization; regulation of cell proliferation; negative regulation of catalytic activity; dendrite development; negative regulation of cell growth; cell cycle arrest |
| NCBI Summary: | This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q96SB3 |
| NCBI GenInfo Identifier: | 90101416 |
| NCBI Gene ID: | 84687 |
| NCBI Accession: | Q96SB3.2 |
| UniProt Secondary Accession: | Q96SB3,Q8TCR9, |
| UniProt Related Accession: | Q96SB3 |
| Molecular Weight: | 815 |
| NCBI Full Name: | Neurabin-2 |
| NCBI Synonym Full Names: | protein phosphatase 1, regulatory subunit 9B |
| NCBI Official Symbol: | PPP1R9B |
| NCBI Official Synonym Symbols: | Spn; SPINO; PPP1R6; PPP1R9 |
| NCBI Protein Information: | neurabin-2; neurabin-II; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin |
| UniProt Protein Name: | Neurabin-2 |
| UniProt Synonym Protein Names: | Neurabin-II; Protein phosphatase 1 regulatory subunit 9B; Spinophilin |
| UniProt Gene Name: | PPP1R9B |
| UniProt Entry Name: | NEB2_HUMAN |
