Developmental Biology
Anti-POU4F3 Antibody (CAB7712)
- SKU:
- CAB7712
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-POU4F3 Antibody |
| Antibody SKU: | CAB7712 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human POU4F3 (NP_002691.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human POU4F3 (NP_002691.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MMAM NSKQ PFGM HPVL QEPK FSSL HSGS EAMR RVCL PAPQ LQGN IFGS FDES LLAR AEAL AAVD IVSH GKNH PFKP DATY HTMS SVPC TSTS STVP ISHP AALT SHPH HAVH QGLE GDLL EHIS PTLS VSGL GAPE HSVM PAQI HPHH LGAM GHLH QAMG MSHP HTVA PHSA MPAC LSDV |
| Gene ID: | 5459 |
| Uniprot: | Q15319 |
| Cellular Location: | Nucleus |
| Calculated MW: | 37kDa |
| Observed MW: | 37kDa |
| Synonyms: | POU4F3, BRN3C, DFNA15, DFNA42, DFNA52 |
| Background: | This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. |
| UniProt Protein Function: | Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear. |
| NCBI Summary: | This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q15319 |
| NCBI GenInfo Identifier: | 4505965 |
| NCBI Gene ID: | 5459 |
| NCBI Accession: | NP_002691.1 |
| UniProt Secondary Accession: | Q15319,O60557, Q2M3F8, |
| UniProt Related Accession: | Q15319 |
| Molecular Weight: | 37,052 Da |
| NCBI Full Name: | POU domain, class 4, transcription factor 3 |
| NCBI Synonym Full Names: | POU class 4 homeobox 3 |
| NCBI Official Symbol: | POU4F3 |
| NCBI Official Synonym Symbols: | BRN3C; DFNA15; DFNA42; DFNA52 |
| NCBI Protein Information: | POU domain, class 4, transcription factor 3 |
| UniProt Protein Name: | POU domain, class 4, transcription factor 3 |
| UniProt Synonym Protein Names: | Brain-specific homeobox/POU domain protein 3C; Brain-3C; Brn-3C |
| UniProt Gene Name: | POU4F3 |
 | Western blot analysis of extracts of Jurkat cells, using POU4F3 antibody (CAB7712) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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