Developmental Biology

Anti-POU4F3 Antibody (CAB14049)

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SKU:
CAB14049
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-POU4F3 Antibody
Antibody SKU:CAB14049
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human POU4F3 (NP_002691.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human POU4F3 (NP_002691.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MMAM NSKQ PFGM HPVL QEPK FSSL HSGS EAMR RVCL PAPQ LQGN IFGS FDES LLAR AEAL AAVD IVSH GKNH PFKP DATY HTMS SVPC TSTS STVP ISHP AALT SHPH HAVH QGLE GDLL EHIS PTLS VSGL GAPE HSVM PAQI HPHH LGAM GHLH QAMG MSHP HTVA PHSA MPAC LSDV
Gene ID:5459
Uniprot:Q15319
Cellular Location:Nucleus
Calculated MW:37kDa
Observed MW:37kDa
Synonyms:POU4F3, BRN3C, DFNA15, DFNA42, DFNA52
Background:This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.
UniProt Protein Function:Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear.
NCBI Summary:This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]
UniProt Code:Q15319
NCBI GenInfo Identifier:4505965
NCBI Gene ID:5459
NCBI Accession:NP_002691.1
UniProt Secondary Accession:Q15319,O60557, Q2M3F8,
UniProt Related Accession:Q15319
Molecular Weight:37,052 Da
NCBI Full Name:POU domain, class 4, transcription factor 3
NCBI Synonym Full Names:POU class 4 homeobox 3
NCBI Official Symbol:POU4F3  
NCBI Official Synonym Symbols:BRN3C; DFNA15; DFNA42; DFNA52  
NCBI Protein Information:POU domain, class 4, transcription factor 3
UniProt Protein Name:POU domain, class 4, transcription factor 3
UniProt Synonym Protein Names:Brain-specific homeobox/POU domain protein 3C; Brain-3C; Brn-3C
UniProt Gene Name:POU4F3  
Anti-POU4F3 Antibody (CAB14049)Western blot analysis of extracts of various cell lines, using POU4F3 antibody (CAB14049) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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