Signal Transduction Antibodies 2

Anti-POMK Antibody (CAB15529)

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SKU:
CAB15529
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-POMK Antibody
Antibody SKU:CAB15529
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human POMK (NP_115613.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:mouse kidney, rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human POMK (NP_115613.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEKQ PQNS RRGL APRE VPPA VGLL LIMA LMNT LLYL CLDH FFIA PRQS TVDP THCP YGHF RIGQ MKNC SPWL SCEE LRTE VRQL KRVG EGAV KRVF LSEW KEHK VALS QLTS LEMK DDFL HGLQ MLKS LQGT HVVT LLGY CEDD NTML TEYH PLGS LSNL EETL NLSK YQNV NTWQ HRLE LAMD YVSI INYL HHSP VGTR VMCD SNDL PKTL SQYL LTSN FSIL ANDL DALP LVNH SSGM LVKC GHRE LHGD FVAP EQLW PYGE DVPF HDDL MPSY DEKI DIWK IPDI SSFL LGHI EGSD MVRF HLFD IHKA CKSQ TPSE RPTA QDVL ETYQ KVLD TLRD AMMS QARE ML
Gene ID:84197
Uniprot:Q9H5K3
Cellular Location:Endoplasmic reticulum membrane, Single-pass type II membrane protein
Calculated MW:40kDa
Observed MW:45kDa
Synonyms:POMK, MDDGA12, MDDGC12, SGK196
Background:This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:POMK: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.1.183; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Membrane protein, integral; Protein kinase, Other; Other group; Other-Unique family

Chromosomal Location of Human Ortholog: 8p11.21

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function:ATP binding; carbohydrate kinase activity; phosphotransferase activity, alcohol group as acceptor; protein kinase activity

Biological Process: brain development; carbohydrate phosphorylation; learning and/or memory; neuromuscular process; neuron migration; protein amino acid O-linked glycosylation; protein amino acid phosphorylation; sensory perception of pain

Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 12; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 12

NCBI Summary:This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Code:Q9H5K3
NCBI GenInfo Identifier:485836935
NCBI Gene ID:84197
NCBI Accession:NP_001264900.1
UniProt Related Accession:Q9H5K3
Molecular Weight:40,050 Da
NCBI Full Name:protein O-mannose kinase
NCBI Synonym Full Names:protein-O-mannose kinase
NCBI Official Symbol:POMK  
NCBI Official Synonym Symbols:SGK196; MDDGA12; MDDGC12  
NCBI Protein Information:protein O-mannose kinase
UniProt Protein Name:Protein O-mannose kinase
UniProt Synonym Protein Names:Protein kinase-like protein SgK196; Sugen kinase 196
Protein Family:Protein O-mannose kinase
UniProt Gene Name:POMK  
UniProt Entry Name:SG196_HUMAN
Anti-POMK Antibody (CAB15529)Western blot analysis of extracts of various cell lines, using POMK antibody (CAB15529) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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