Epigenetics & Nuclear Signaling Antibodies 5
Anti-POLD1 Antibody (CAB4218)
- SKU:
- CAB4218
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-POLD1 Antibody |
| Antibody SKU: | CAB4218 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human POLD1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, A-549, Jurkat, Mouse testis, Rat testis |
| Immunogen: | A synthesized peptide derived from human POLD1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5424 |
| Uniprot: | P28340 |
| Cellular Location: | |
| Calculated MW: | 124kDa |
| Observed MW: | 130KDa |
| Synonyms: | CDC2, CRCS10, MDPL, POLD |
| Background: | This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012] |
| UniProt Protein Function: | POLD1: Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex. Belongs to the DNA polymerase type-B family. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.7.7.7; Nucleotide Metabolism - pyrimidine; Hydrolase; DNA replication; DNA repair, damage; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: cytoplasm; delta DNA polymerase complex; membrane; nuclear chromosome, telomeric region; nucleoplasm; nucleotide-excision repair complex; nucleus Molecular Function:3'-5'-exodeoxyribonuclease activity; chromatin binding; damaged DNA binding; DNA binding; DNA-directed DNA polymerase activity; protein binding Biological Process: base-excision repair, gap-filling; bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA repair; DNA replication; DNA replication proofreading; DNA strand elongation during DNA replication; DNA synthesis during DNA repair; fatty acid homeostasis; mismatch repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; response to UV; telomere maintenance; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair Disease: Colorectal Cancer, Susceptibility To, 10; Mandibular Hypoplasia, Deafness, Progeroid Features, And Lipodystrophy Syndrome |
| NCBI Summary: | This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P28340 |
| NCBI GenInfo Identifier: | 50403732 |
| NCBI Gene ID: | 5424 |
| NCBI Accession: | P28340.2 |
| UniProt Secondary Accession: | P28340,Q8NER3, Q96H98, |
| UniProt Related Accession: | P28340 |
| Molecular Weight: | 123,631 Da |
| NCBI Full Name: | DNA polymerase delta catalytic subunit |
| NCBI Synonym Full Names: | DAN polymerase delta 1, catalytic subunit |
| NCBI Official Symbol: | POLD1 |
| NCBI Official Synonym Symbols: | CDC2; MDPL; POLD; CRCS10 |
| NCBI Protein Information: | DNA polymerase delta catalytic subunit |
| UniProt Protein Name: | DNA polymerase delta catalytic subunit |
| UniProt Synonym Protein Names: | DNA polymerase subunit delta p125 |
| Protein Family: | DNA polymerase |
| UniProt Gene Name: | POLD1 |
| UniProt Entry Name: | DPOD1_HUMAN |
 | Western blot - POLD1 Rabbit mAb (CAB4218) |
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