Epigenetics & Nuclear Signaling Antibodies 3
Anti-PNN Antibody (CAB16955)
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- SKU:
- CAB16955
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-PNN Antibody |
| Antibody SKU: | CAB16955 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNN (NP_002678.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | LO2, PC-12 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNN (NP_002678.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAVA VRTL QEQL EKAK ESLK NVDE NIRK LTGR DPND VRPI QARL LALS GPGG GRGR GSLL LRRG FSDS GGGP PAKQ RDLE GAVS RLGG ERRT RRES RQES |
| Gene ID: | 5411 |
| Uniprot: | Q9H307 |
| Cellular Location: | |
| Calculated MW: | 67kDa/81kDa |
| Observed MW: | 140kDa |
| Synonyms: | PNN, DRS, DRSP, SDK3, memA, pinin |
| Background: |
| UniProt Protein Function: | Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. |
| UniProt Code: | Q9H307 |
| NCBI GenInfo Identifier: | 1375418694 |
| NCBI Gene ID: | 5411 |
| NCBI Accession: | Q9H307.5 |
| UniProt Secondary Accession: | Q9H307,O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9 Q9UQR9, B4DZX8, |
| UniProt Related Accession: | Q9H307 |
| Molecular Weight: | 81,628 Da |
| NCBI Full Name: | Pinin |
| NCBI Synonym Full Names: | pinin, desmosome associated protein |
| NCBI Official Symbol: | PNN |
| NCBI Official Synonym Symbols: | DRS; DRSP; SDK3; memA |
| NCBI Protein Information: | pinin |
| UniProt Protein Name: | Pinin |
| UniProt Synonym Protein Names: | 140 kDa nuclear and cell adhesion-related phosphoprotein; Desmosome-associated protein; Domain-rich serine protein; DRS protein; DRSP; Melanoma metastasis clone A protein; Nuclear protein SDK3; SR-like protein |
| Protein Family: | Pinin |
| UniProt Gene Name: | PNN |
 | Western blot analysis of extracts of various cell lines, using PNN antibody (CAB16955) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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