ChIP Antibodies
Anti-PMVK Antibody (CAB13866)
- SKU:
- CAB13866
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Antibody Name: | Anti-PMVK Antibody |
Antibody SKU: | CAB13866 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human PMVK (NP_006547.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | 293T, LO2, A-431, HeLa |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-192 of human PMVK (NP_006547.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MAPL GGAP RLVL LFSG KRKS GKDF VTEA LQSR LGAD VCAV LRLS GPLK EQYA QEHG LNFQ RLLD TSTY KEAF RKDM IRWG EEKR QADP GFFC RKIV EGIS QPIW LVSD TRRV SDIQ WFRE AYGA VTQT VRVV ALEQ SRQQ RGWV FTPG VDDA ESEC GLDN FGDF DWVI ENHG VEQR LEEQ LENL IEFI RSRL |
Gene ID: | 10654 |
Uniprot: | Q15126 |
Cellular Location: | Peroxisome |
Calculated MW: | 21kDa |
Observed MW: | 22kDa |
Synonyms: | PMVK, HUMPMKI, PMK, PMKA, PMKASE, POROK1 |
Background: | This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | PMVK: Induced by sterol. Monomer. |
UniProt Protein Details: | Protein type:Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.7.4.2; Kinase, other Chromosomal Location of Human Ortholog: 1q22 Cellular Component: membrane; peroxisome; cytosol Molecular Function:phosphomevalonate kinase activity; ATP binding Biological Process: isopentenyl diphosphate biosynthetic process, mevalonate pathway; sterol biosynthetic process; phosphorylation; cholesterol biosynthetic process |
NCBI Summary: | This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q15126 |
NCBI GenInfo Identifier: | 3024422 |
NCBI Gene ID: | 10654 |
NCBI Accession: | Q15126.3 |
UniProt Secondary Accession: | Q15126,Q5TZW9, |
UniProt Related Accession: | Q15126 |
Molecular Weight: | 21,995 Da |
NCBI Full Name: | Phosphomevalonate kinase |
NCBI Synonym Full Names: | phosphomevalonate kinase |
NCBI Official Symbol: | PMVK |
NCBI Official Synonym Symbols: | PMK; PMKA; PMKASE; HUMPMKI |
NCBI Protein Information: | phosphomevalonate kinase; hPMK |
UniProt Protein Name: | Phosphomevalonate kinase |
UniProt Gene Name: | PMVK |
UniProt Entry Name: | PMVK_HUMAN |
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