Cardiovascular Antibodies
Anti-PLGF Antibody (CAB1727)
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- SKU:
- CAB1727
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-PLGF Antibody |
| Antibody SKU: | CAB1727 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-170 of human PLGF (NP_002623.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse liver, HT-29, MCF7, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-170 of human PLGF (NP_002623.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LPAV PPQQ WALS AGNG SSEV EVVP FQEV WGRS YCRA LERL VDVV SEYP SEVE HMFS PSCV SLLR CTGC CGDE NLHC VPVE TANV TMQL LKIR SGDR PSYV ELTF SQHV RCEC RPLR EKMK PERR RPKG RGKR RREK QRPT DCHL CGDA VPRR |
| Gene ID: | 5228 |
| Uniprot: | P49763 |
| Cellular Location: | Secreted |
| Calculated MW: | 16kDa/19kDa/24kDa/27kDa |
| Observed MW: | 25kDa/50kDa |
| Synonyms: | PGF, D12S1900, PGFL, PIGF, PLGF, PlGF-2, SHGC-10760 |
| Background: | This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: extracellular space; membrane; extracellular region Molecular Function:heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; cell differentiation |
| NCBI Summary: | This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011] |
| UniProt Code: | P49763 |
| NCBI GenInfo Identifier: | 17380553 |
| NCBI Gene ID: | 5228 |
| NCBI Accession: | P49763.2 |
| UniProt Secondary Accession: | P49763,Q07101, Q9BV78, Q9Y6S8, |
| UniProt Related Accession: | P49763 |
| Molecular Weight: | 19,338 Da |
| NCBI Full Name: | Placenta growth factor |
| NCBI Synonym Full Names: | placental growth factor |
| NCBI Official Symbol: | PGF |
| NCBI Official Synonym Symbols: | PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760 |
| NCBI Protein Information: | placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein |
| UniProt Protein Name: | Placenta growth factor |
| Protein Family: | Placenta growth factor |
| UniProt Gene Name: | PGF |
| UniProt Entry Name: | PLGF_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLGF antibody (CAB1727) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
 | Western blot analysis of extracts of various cell lines, using PLGF antibody (CAB1727) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s. |
 | Immunohistochemistry of paraffin-embedded human colon using PLGF Antibody (CAB1727) at dilution of 1:100 (40x lens). |
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