Description
Product Name: | Plexin A1 Rabbit mAb |
Product Code: | CAB3698 |
Size: | 20uL, 50uL, 100uL |
Synonyms: | NOV, NOVP, PLEXIN-A1, PLXN1 |
Applications: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human Plexin A1 |
Applications: | WB |
Recommended Dilutions: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | K-562, Mouse brain, Rat testis |
Immunogen: | A synthesized peptide derived from human Plexin A1 |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 5361 |
Uniprot: | Q9UIW2 |
Calculated MW: | 211kDa |
Observed MW: | 250kDa |
UniProt Protein Function: | PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q21.3 Cellular Component: cytoplasm; integral to membrane; plasma membrane; nucleus Molecular Function:semaphorin receptor activity; receptor activity Biological Process: axon guidance; regulation of smooth muscle cell migration; multicellular organismal development |
UniProt Code: | Q9UIW2 |
NCBI GenInfo Identifier: | 313104202 |
NCBI Gene ID: | 5361 |
NCBI Accession: | Q9UIW2.3 |
UniProt Related Accession: | Q9UIW2 |
Molecular Weight: | 211,067 Da |
NCBI Full Name: | Plexin-A1 |
NCBI Synonym Full Names: | plexin A1 |
NCBI Official Symbol: | PLXNA1 |
NCBI Official Synonym Symbols: | NOV; NOVP; PLXN1; PLEXIN-A1 |
NCBI Protein Information: | plexin-A1; plexin 1; semaphorin receptor NOV |
UniProt Protein Name: | Plexin-A1 |
UniProt Synonym Protein Names: | Semaphorin receptor NOV |
Protein Family: | Plexin |
UniProt Gene Name: | PLXNA1 |
UniProt Entry Name: | PLXA1_HUMAN |