Cell Biology Antibodies 18

Anti-PKN2 Antibody (CAB18373)

(No reviews yet) Write a Review
SKU:
CAB18373
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PKN2 Antibody
Antibody SKU:CAB18373
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human PKN2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Rat lung
Immunogen:Recombinant protein of human PKN2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5586
Uniprot:Q16513
Cellular Location:
Calculated MW:75kDa/94kDa/106kDa/110kDa/112kDa
Observed MW:140kDa
Anti-PKN2 Antibody (CAB18373)Western blot - PKN2 Rabbit pAb (CAB18373)
Synonyms:PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7, PKN2
Background:
UniProt Protein Function:PKN2: an AGC kinase of the PKN family. A PKC-related serine/threonine-protein kinase and Rho/Rac effector protein. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcriptional activation. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in an ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. Kinase activity is activated upon binding to GTP-bound Rhoa/Rac1 GTPases. Activated by limited proteolysis with trypsin, and withn caspase-3 (CASP3) during apoptosis. Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. Five isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.7.11.13; Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; PKN family

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: nucleoplasm; apical junction complex; centrosome; intermediate filament cytoskeleton; lamellipodium; perinuclear region of cytoplasm; cytoplasm; plasma membrane; midbody; cell junction; nucleus; cleavage furrow

Molecular Function:protein serine/threonine kinase activity; protein binding; protein kinase C activity; histone deacetylase binding; kinase activity; ATP binding; protein kinase activity

Biological Process: positive regulation of cytokinesis; positive regulation of viral genome replication; apical junction assembly; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cell division; apoptosis; positive regulation of mitotic cell cycle; signal transduction; cell adhesion; cell cycle; protein amino acid phosphorylation

UniProt Code:Q16513
NCBI GenInfo Identifier:6225859
NCBI Gene ID:5586
NCBI Accession:Q16513.1
UniProt Related Accession:Q16513
Molecular Weight:Observed: 140 kDaPredicted: 113 kDa
NCBI Full Name:Serine/threonine-protein kinase N2
NCBI Synonym Full Names:protein kinase N2
NCBI Official Symbol:PKN2  
NCBI Official Synonym Symbols:PAK2; PRK2; STK7; Pak-2; PRKCL2; PRO2042  
NCBI Protein Information:serine/threonine-protein kinase N2
UniProt Protein Name:Serine/threonine-protein kinase N2
UniProt Synonym Protein Names:PKN gamma; Protein kinase C-like 2; Protein-kinase C-related kinase 2
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:PKN2  
UniProt Entry Name:PKN2_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products