Metabolism Antibodies 1
Anti-PKD1 Antibody (CAB14200)
- SKU:
- CAB14200
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Antibody Name: | Anti-PKD1 Antibody |
Antibody SKU: | CAB14200 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 3700-3860 of human PKD1 (NP_001009944.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 3700-3860 of human PKD1 (NP_001009944.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | RLQS AIKQ ELHS RAFL AITR SEEL WPWM AHVL LPYV HGNQ SSPE LGPP RLRQ VRLQ EALY PDPP GPRV HTCS AAGG FSTS DYDV GWES PHNG SGTW AYSA PDLL GAWS WGSC AVYD SGGY VQEL GLSL EESR DRLR FLQL HNWL DNRS RAVF LELT RYSP A |
Gene ID: | 5310 |
Uniprot: | P98161 |
Cellular Location: | Cell projection, Membrane, Multi-pass membrane protein, cilium |
Calculated MW: | 462kDa |
Observed MW: | Refer to Figures |
Synonyms: | PKD1, PBP, PC1, Pc-1, TRPP1 |
Background: | This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. |
UniProt Protein Function: | Involved in renal tubulogenesis (PubMed:12482949). Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions. |
NCBI Summary: | This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008] |
UniProt Code: | P98161 |
NCBI GenInfo Identifier: | 205360962 |
NCBI Gene ID: | 5310 |
NCBI Accession: | NP_000287.3 |
UniProt Secondary Accession: | P98161,Q15140, Q15141, |
UniProt Related Accession: | P98161 |
Molecular Weight: | 462,401 Da |
NCBI Full Name: | polycystin-1 isoform 2 |
NCBI Synonym Full Names: | polycystin 1, transient receptor potential channel interacting |
NCBI Official Symbol: | PKD1 |
NCBI Official Synonym Symbols: | PBP; PC1; Pc-1; TRPP1 |
NCBI Protein Information: | polycystin-1 |
UniProt Protein Name: | Polycystin-1 |
UniProt Synonym Protein Names: | Autosomal dominant polycystic kidney disease 1 protein |
Protein Family: | Polycystin |
UniProt Gene Name: | PKD1 |
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