Cell Biology Antibodies 7

Anti-PITX2 Antibody (CAB1870)

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SKU:
CAB1870
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PITX2 Antibody
Antibody SKU:CAB1870
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PITX2 (NP_000316.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:NCI-H490, HeLa, Mouse brain, Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PITX2 (NP_000316.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNCM KGPL HLEH RAAG TKLS AVSS SSCH HPQP LAMA SVLA PGQP RSLD SSKH RLEV HTIS DTSS PEAA EKDK SQQG KNED VGAE DPSK KKRQ RRQR THFT
Gene ID:5308
Uniprot:Q99697
Cellular Location:Nucleus
Calculated MW:30kDa/35kDa
Observed MW:39kDa
Synonyms:PITX2, ARP1, ASGD4, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
Background:This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
UniProt Protein Function:Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo.
NCBI Summary:This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Code:Q99697
NCBI GenInfo Identifier:6174907
NCBI Gene ID:5308
NCBI Accession:Q99697.2
UniProt Secondary Accession:Q99697,O60578, O60579, O60580, Q3KQX9, Q9BY17, A8K6C6 B2RA02, B3KXS0,
UniProt Related Accession:Q99697
Molecular Weight:30,336 Da
NCBI Full Name:Pituitary homeobox 2
NCBI Synonym Full Names:paired like homeodomain 2
NCBI Official Symbol:PITX2  
NCBI Official Synonym Symbols:RS; RGS; ARP1; Brx1; IDG2; IGDS; IHG2; PTX2; RIEG; IGDS2; IRID2; Otlx2; RIEG1  
NCBI Protein Information:pituitary homeobox 2
UniProt Protein Name:Pituitary homeobox 2
UniProt Synonym Protein Names:ALL1-responsive protein ARP1; Homeobox protein PITX2; Paired-like homeodomain transcription factor 2; RIEG bicoid-related homeobox transcription factor; Solurshin
Protein Family:Pituitary homeobox
UniProt Gene Name:PITX2  
UniProt Entry Name:PITX2_HUMAN
Anti-PITX2 Antibody (CAB1870)Western blot analysis of extracts of various cell lines, using PITX2 antibody (CAB1870) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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