Cell Biology Antibodies 11
Anti-PIK3R3 Antibody (CAB7942)
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- SKU:
- CAB7942
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PIK3R3 Antibody |
| Antibody SKU: | CAB7942 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PIK3R3 (NP_003620.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Mouse kidney, Rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PIK3R3 (NP_003620.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MYNT VWSM DRDD ADWR EVMM PYST ELIF YIEM DPPA LPPK PPKP MTSA VPNG MKDS SVSL QDAE WYWG DISR EEVN DKLR DMPD GTFL VRDA STKM QGDY TLTL RKGG NNKL IKIY HRDG KYGF SDPL TFNS VVEL INHY HHES LAQY NPKL DVKL MYPV SRYQ QDQL VKED NIDA VGKK LQEY HSQY QEKS KEYD RLYE EYTR TSQE IQMK RTAI EAFN ETIK IFEE QC |
| Gene ID: | 8503 |
| Uniprot: | Q92569 |
| Cellular Location: | |
| Calculated MW: | 43kDa/47kDa/54kDa |
| Observed MW: | 55kDa |
| Synonyms: | PIK3R3, p55, p55-GAMMA, p55PIK |
| Background: | Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. |
| UniProt Protein Function: | PIK3R3: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Belongs to the PI3K p85 subunit family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Kinase, lipid Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: cytosol; phosphoinositide 3-kinase complex Molecular Function:protein binding; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity Biological Process: phospholipid metabolic process; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; regulation of phosphoinositide 3-kinase activity |
| NCBI Summary: | Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016] |
| UniProt Code: | Q92569 |
| NCBI GenInfo Identifier: | 317373310 |
| NCBI Gene ID: | 8503 |
| NCBI Accession: | Q92569.2 |
| UniProt Related Accession: | Q92569 |
| Molecular Weight: | |
| NCBI Full Name: | Phosphatidylinositol 3-kinase regulatory subunit gamma |
| NCBI Synonym Full Names: | phosphoinositide-3-kinase regulatory subunit 3 |
| NCBI Official Symbol: | PIK3R3 |
| NCBI Official Synonym Symbols: | p55; p55PIK; p55-GAMMA |
| NCBI Protein Information: | phosphatidylinositol 3-kinase regulatory subunit gamma |
| UniProt Protein Name: | Phosphatidylinositol 3-kinase regulatory subunit gamma |
| UniProt Synonym Protein Names: | Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; PI3-kinase subunit p55-gamma; PtdIns-3-kinase regulatory subunit p55-gamma; p55PIK |
| UniProt Gene Name: | PIK3R3 |
| UniProt Entry Name: | P55G_HUMAN |
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