Cell Biology Antibodies 5
Anti-PICK1 Antibody (CAB1519)
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- SKU:
- CAB1519
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PICK1 Antibody |
| Antibody SKU: | CAB1519 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 260-360 of human PICK1 (NP_036539.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HL-60, Jurkat, K-562, SH-SY5Y, HT-29, SW620 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 260-360 of human PICK1 (NP_036539.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YLSY CLKV KEMD DEEY SCIA LGEP LYRV STGN YEYR LILR CRQE ARAR FSQM RKDV LEKM ELLD QKHV QDIV FQLQ RLVS TMSK YYND CYAV LRDA DVFP I |
| Gene ID: | 9463 |
| Uniprot: | Q9NRD5 |
| Cellular Location: | Cell junction, Cytoplasm, Lipid-anchor, Membrane, Peripheral membrane protein, cytoskeleton, perinuclear region, postsynaptic cell membrane, postsynaptic density, synapse, synaptosome |
| Calculated MW: | 39kDa/46kDa |
| Observed MW: | 53kDa |
| Synonyms: | PICK1, PICK, PRKCABP |
| Background: | The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | PICK1: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Ligand, receptor tyrosine kinase; Adaptor/scaffold Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: presynaptic membrane; Golgi apparatus; postsynaptic membrane; neuron projection; cytoskeleton; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; synapse; cell junction Molecular Function:actin filament binding; protein C-terminus binding; identical protein binding; protein domain specific binding; protein binding; enzyme binding; G-protein-coupled receptor binding; protein kinase C binding; metal ion binding; ATPase activity; receptor binding Biological Process: glial cell development; cellular response to glucose starvation; synaptic transmission; DNA methylation during gametogenesis; monoamine transport; positive regulation of receptor internalization; protein kinase C activation; retrograde vesicle-mediated transport, Golgi to ER; DNA methylation during embryonic development; neuronal ion channel clustering; protein amino acid phosphorylation; receptor clustering; protein targeting |
| NCBI Summary: | The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRD5 |
| NCBI GenInfo Identifier: | 22095990 |
| NCBI Gene ID: | 9463 |
| NCBI Accession: | Q9NRD5.2 |
| UniProt Secondary Accession: | Q9NRD5,O95906, B3KS52, |
| UniProt Related Accession: | Q9NRD5 |
| Molecular Weight: | 415 |
| NCBI Full Name: | PRKCA-binding protein |
| NCBI Synonym Full Names: | protein interacting with PRKCA 1 |
| NCBI Official Symbol: | PICK1 |
| NCBI Official Synonym Symbols: | PICK; PRKCABP |
| NCBI Protein Information: | PRKCA-binding protein; protein interacting with C kinase 1; protein kinase C-alpha-binding protein |
| UniProt Protein Name: | PRKCA-binding protein |
| UniProt Synonym Protein Names: | Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein |
| Protein Family: | PRKCA-binding protein |
| UniProt Gene Name: | PICK1 |
| UniProt Entry Name: | PICK1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PICK1 antibody (CAB1519) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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