Cell Biology Antibodies 4

Anti-PICK1 Antibody (CAB13574)

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SKU:
CAB13574
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PICK1 Antibody
Antibody SKU:CAB13574
Antibody Size:20uL, 50uL, 100uL
Application:IHC IF
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 260-360 of human PICK1 (NP_036539.1).
Application:IHC IF
Recommended Dilution:IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 260-360 of human PICK1 (NP_036539.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YLSY CLKV KEMD DEEY SCIA LGEP LYRV STGN YEYR LILR CRQE ARAR FSQM RKDV LEKM ELLD QKHV QDIV FQLQ RLVS TMSK YYND CYAV LRDA DVFP I
Gene ID:9463
Uniprot:Q9NRD5
Cellular Location:Cell junction, Cytoplasm, Lipid-anchor, Membrane, Peripheral membrane protein, cytoskeleton, perinuclear region, postsynaptic cell membrane, postsynaptic density, synapse, synaptosome
Calculated MW:39kDa/46kDa
Observed MW:
Synonyms:PICK1, PICK, PRKCABP
Background:The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
UniProt Protein Function:PICK1: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.
UniProt Protein Details:

Protein type:Cell development/differentiation; Ligand, receptor tyrosine kinase; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: presynaptic membrane; Golgi apparatus; postsynaptic membrane; neuron projection; cytoskeleton; mitochondrion; perinuclear region of cytoplasm; cytoplasm; plasma membrane; synapse; cell junction

Molecular Function:actin filament binding; protein C-terminus binding; identical protein binding; protein domain specific binding; protein binding; enzyme binding; G-protein-coupled receptor binding; protein kinase C binding; metal ion binding; ATPase activity; receptor binding

Biological Process: glial cell development; cellular response to glucose starvation; synaptic transmission; DNA methylation during gametogenesis; monoamine transport; positive regulation of receptor internalization; protein kinase C activation; retrograde vesicle-mediated transport, Golgi to ER; DNA methylation during embryonic development; neuronal ion channel clustering; protein amino acid phosphorylation; receptor clustering; protein targeting

NCBI Summary:The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NRD5
NCBI GenInfo Identifier:22095990
NCBI Gene ID:9463
NCBI Accession:Q9NRD5.2
UniProt Secondary Accession:Q9NRD5,O95906, B3KS52,
UniProt Related Accession:Q9NRD5
Molecular Weight:415
NCBI Full Name:PRKCA-binding protein
NCBI Synonym Full Names:protein interacting with PRKCA 1
NCBI Official Symbol:PICK1  
NCBI Official Synonym Symbols:PICK; PRKCABP  
NCBI Protein Information:PRKCA-binding protein; protein interacting with C kinase 1; protein kinase C-alpha-binding protein
UniProt Protein Name:PRKCA-binding protein
UniProt Synonym Protein Names:Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein
Protein Family:PRKCA-binding protein
UniProt Gene Name:PICK1  
UniProt Entry Name:PICK1_HUMAN
Anti-PICK1 Antibody (CAB13574)Immunohistochemistry of paraffin-embedded human colon using PICK1 antibody (CAB13574) at dilution of 1:100 (40x lens).
Anti-PICK1 Antibody (CAB13574)Immunohistochemistry of paraffin-embedded human prostate using PICK1 antibody (CAB13574) at dilution of 1:100 (40x lens).
Anti-PICK1 Antibody (CAB13574)Immunohistochemistry of paraffin-embedded human prostate cancer using PICK1 antibody (CAB13574) at dilution of 1:100 (40x lens).
Anti-PICK1 Antibody (CAB13574)Immunohistochemistry of paraffin-embedded human gastric cancer using PICK1 antibody (CAB13574) at dilution of 1:100 (40x lens).
Anti-PICK1 Antibody (CAB13574)Immunofluorescence analysis of HeLa cells using PICK1 antibody (CAB13574). Blue: DAPI for nuclear staining.
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