Cell Biology Antibodies 16
Anti-Phospho-VASP-S239 Antibody (CABP0187)
- SKU:
- CABP0187
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-Phospho-VASP-S239 Antibody |
Antibody SKU: | CABP0187 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A phospho specific peptide corresponding to residues surrounding S239 of human VASP |
Application: | WB IHC |
Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | 293T |
Immunogen: | A phospho specific peptide corresponding to residues surrounding S239 of human VASP |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 7408 |
Uniprot: | P50552 |
Cellular Location: | Cell junction, Cell projection, Cytoplasm, cytoskeleton, filopodium membrane, focal adhesion, lamellipodium membrane, tight junction |
Calculated MW: | 39kDa |
Observed MW: | 50kDa |
Synonyms: | VASP |
Background: | Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. |
UniProt Protein Function: | VASP: vasodilator-stimulated phosphoprotein. Actin- and profilin-binding microfilament-associated protein. The phosphorylation of VASP is dynamically regulated by cellular adhesion to extracellular matrix. |
UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: filopodium membrane; tight junction; focal adhesion; cytoplasm; plasma membrane; cytosol; actin cytoskeleton Molecular Function:protein binding; actin binding; SH3 domain binding; profilin binding Biological Process: axon guidance; positive regulation of actin filament polymerization; actin polymerization and/or depolymerization; neural tube closure; T cell receptor signaling pathway; protein homotetramerization |
NCBI Summary: | Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008] |
UniProt Code: | P50552 |
NCBI GenInfo Identifier: | 1718079 |
NCBI Gene ID: | 7408 |
NCBI Accession: | P50552.3 |
UniProt Secondary Accession: | P50552,Q6PIZ1, Q93035, B2RBT9, |
UniProt Related Accession: | P50552 |
Molecular Weight: | 380 |
NCBI Full Name: | Vasodilator-stimulated phosphoprotein |
NCBI Synonym Full Names: | vasodilator-stimulated phosphoprotein |
NCBI Official Symbol: | VASP |
NCBI Protein Information: | vasodilator-stimulated phosphoprotein |
UniProt Protein Name: | Vasodilator-stimulated phosphoprotein |
Protein Family: | Vasodilator-stimulated phosphoprotein |
UniProt Gene Name: | VASP |
UniProt Entry Name: | VASP_HUMAN |