Metabolism Antibodies 3

Anti-Phospho-PLCB3-S1105 pAb Antibody (CABP0837)

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SKU:
CABP0837
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-Phospho-PLCB3-S1105 Antibody
Antibody SKU:CABP0837
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around S1105 of human PLCB3 (NP_000923.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa
Immunogen:A synthetic phosphorylated peptide around S1105 of human PLCB3 (NP_000923.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HNSI S
Gene ID:5331
Uniprot:Q01970
Cellular Location:Membrane, Peripheral membrane protein
Calculated MW:131kDa/138kDa
Observed MW:150kDa
Anti-Phospho-PLCB3-S1105 pAb (CABP0837)Western blot analysis of extracts of HeLa cells, using Phospho-PLCB3-S1105 antibody (CABP0837) at 1:1000 dilution. HeLa cells were treated by PMA/TPA (200nM) for 15 minutes after serum-starvation overnight. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Synonyms:PLCB3
Background:This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1, 4, 5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:PLCB3: a phosphatidylinositol-specific phospholipase C. Binds to calmodulin. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate.
UniProt Protein Details:

Protein type:Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytosol; nucleoplasm; protein complex; sarcolemma

Molecular Function:calcium ion binding; calmodulin binding; phosphoinositide phospholipase C activity; phospholipase C activity; signal transducer activity

Biological Process: G-protein coupled receptor protein signaling pathway; inositol phosphate metabolic process; lipid catabolic process; post-Golgi vesicle-mediated transport; regulation of systemic arterial blood pressure; synaptic transmission

NCBI Summary:This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Code:Q01970
NCBI GenInfo Identifier:1730573
NCBI Gene ID:5331
NCBI Accession:Q01970.2
UniProt Secondary Accession:Q01970,Q8N1A4, A5PKZ6, G5E960,
UniProt Related Accession:Q01970
Molecular Weight:131,205 Da
NCBI Full Name:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
NCBI Synonym Full Names:phospholipase C beta 3
NCBI Official Symbol:PLCB3  
NCBI Protein Information:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
UniProt Protein Name:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
UniProt Synonym Protein Names:Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3
Protein Family:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
UniProt Gene Name:PLCB3  
UniProt Entry Name:PLCB3_HUMAN
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