Cell Biology Antibodies 16

Anti-Phospho-MAPK8-T183/Y185 + MAPK9-T183/Y185 + MAPK10-T221/Y223 Antibody (CABP0276)

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SKU:
CABP0276
Product Type:
Antibody
Applications:
WB
Applications:
IF
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Phospho-MAPK8-T183/Y185 + MAPK9-T183/Y185 + MAPK10-T221/Y223 Antibody
Antibody SKU:CABP0276
Antibody Size:50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding T183 of human JNK1
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:C6
Immunogen:A phospho specific peptide corresponding to residues surrounding T183 of human JNK1
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5599/5601/5602
Uniprot:P45983/P45984/P53779
Cellular Location:
Calculated MW:35kDa/44kDa/48kDa/27kDa/52kDa
Observed MW:46kDa, 54kDa
Anti-Phospho-MAPK8-T183/Y185 + MAPK9-T183/Y185 + MAPK10-T221/Y223 Antibody (CABP0276)Western blot analysis of extracts from C6 cells untreated or treated with anisomycin using Phospho-JNK1-T183/Y185 + JNK2-T183/Y185 + JNK3-T221/Y223 Antibody (CABP0276). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA.
Synonyms:JNK1/JNK2/JNK3
Background:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
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